Is very short-course antibiotic therapy possible in postoperative intra-abdominal infections? Discussion on “Short-course antibiotic therapy for critically ill patients treated for postoperative intra-abdominal infection: the DURAPOP randomised clinical trial”

Montravers P, Tubach F, Lescot T, Veber B, Esposito-Farèse M, Seguin P et al (2018) Short-course antibiotic therapy for critically ill patients treated for postoperative intra-abdominal infection: the DURAPOP randomised clinical trial. Intensive Care Med 44(3):300–310.  https://doi.org/10.1007/s00134-018-5088-x CrossRefPubMedGoogle Scholar

Sawyer RG, Claridge JA, Nathens AB, Rotstein OD, Duane TM, Evans HL et al (2015) Trial of short-course antimicrobial therapy for intraabdominal infection. N Engl J Med 372(21):1996–2005CrossRefPubMedPubMedCentralGoogle Scholar

Maseda E, Suarez-de-la-Rica A, Anillo V, Tamayo E, García-Bernedo CA, Ramasco F et al (2015) Procalcitonin-guided therapy may reduce length of antibiotic treatment in intensive care unit patients with secondary peritonitis: a multicenter retrospective study. J Crit Care 30(3):537–542CrossRefPubMedGoogle Scholar

Bouadma L, Luyt CE, Tubach F, Cracco C, Alvarez A, Schwebel C, Schortgen F, Lasocki S, Veber B, Dehoux M, Bernard M, Pasquet B, Regnier B, Brun-Buisson C, Chastre J, Wolff M (2010) Use of procalcitonin to reduce patients’ exposure to antibiotics in intensive care units (PRORATA trial): a multicentre randomised controlled trial. Lancet 375:463–474CrossRefPubMedGoogle Scholar

Jung B, Molinari N, Nasri M, Hajjej Z, Chanques G, Jean-Pierre H, Panaro F, Jaber S (2013) Procalcitonin biomarker kinetics fails to predict treatment response in perioperative abdominal infection with septic shock. Crit Care 17:R255CrossRefPubMedPubMedCentralGoogle Scholar