References
Shankar-Hari M, Spencer J, Sewell WA, Rowan KM, Singer M (2012) Bench-to-bedside review: immunoglobulin therapy for sepsis—biological plausibility from a critical care perspective. Crit Care 16:206
Shankar-Hari M, Culshaw N, Post B, Tamayo E, Andaluz-Ojeda D, Bermejo-Martin JF, Dietz S, Werdan K, Beale R, Spencer J, Singer M (2015) Endogenous IgG hypogammaglobulinaemia in critically ill adults with sepsis: systematic review and meta-analysis. Intensive Care Med 41:1393–1401
Shankar-Hari M, Singer M, Spencer J (2017) Can Concurrent abnormalities in free light chains and immunoglobulin concentrations identify a target population for immunoglobulin trials in sepsis? Crit Care Med 45:1829–1836
Bermejo-Martin JF, Rodriguez-Fernandez A, Herran-Monge R, Andaluz-Ojeda D, Muriel-Bombin A, Merino P, Garcia-Garcia MM, Citores R, Gandia F, Almansa R, Blanco J, Group G (2014) Immunoglobulins IgG1, IgM and IgA: a synergistic team influencing survival in sepsis. J Intern Med 276:404–412
Martin-Loeches I, Muriel-Bombin A, Ferrer R, Artigas A, Sole-Violan J, Lorente L, Andaluz-Ojeda D, Prina-Mello A, Herran-Monge R, Suberviola B, Rodriguez-Fernandez A, Merino P, Loza AM, Garcia-Olivares P, Anton E, Tamayo E, Trapiello W, Blanco J, Bermejo-Martin JF, group G (2017) The protective association of endogenous immunoglobulins against sepsis mortality is restricted to patients with moderate organ failure. Ann Intensive Care 7:44
Giamarellos-Bourboulis EJ, Apostolidou E, Lada M, Perdios I, Gatselis NK, Tsangaris I, Georgitsi M, Bristianou M, Kanni T, Sereti K, Kyprianou MA, Kotanidou A, Armaganidis A, Hellenic Sepsis Study Group (2013) Kinetics of circulating immunoglobulin M in sepsis: relationship with final outcome. Crit Care 17:R247
Nakano T, Matsui M, Inoue I, Awata T, Katayama S, Murakoshi T (2011) Free immunoglobulin light chain: its biology and implications in diseases. Clin Chim Acta 412:843–849
Shankar-Hari M, Fear D, Lavender P, Mare T, Beale R, Swanson C, Singer M, Spencer J (2017) Activation-associated accelerated apoptosis of memory B cells in critically ill patients with sepsis. Crit Care Med 45:875–882
Soares MO, Welton NJ, Harrison DA, Peura P, Shankar- Hari M, Harvey SE, Madan JJ, Ades AE, Palmer SJ, Rowan KM (2012) An evaluation of the feasibility, cost and value of information of a multicentre randomised controlled trial of intravenous immunoglobulin for sepsis (severe sepsis and septic shock): incorporating a systematic review, meta-analysis and value of information analysis. Health Technol Assess 16:1–186
Turgeon AF, Hutton B, Fergusson DA, McIntyre L, Tinmouth AA, Cameron DW, Hebert PC (2007) Meta-analysis: intravenous immunoglobulin in critically ill adult patients with sepsis. Ann Intern Med 146:193–203
Shankar-Hari M, Harrison DA, Rowan KM (2016) Differences in impact of definitional elements on mortality precludes international comparisons of sepsis epidemiology-a cohort study illustrating the need for standardized reporting. Crit Care Med 44:2223–2230
Burnham KL, Davenport EE, Radhakrishnan J, Humburg P, Gordon AC, Hutton P, Svoren-Jabalera E, Garrard C, Hill AVS, Hinds CJ, Knight JC (2017) Shared and distinct aspects of the sepsis transcriptomic response to fecal peritonitis and pneumonia. Am J Respir Crit Care Med 196:328–339
Shankar-Hari M, Rubenfeld GD (2017) The use of enrichment to reduce statistically indeterminate or negative trials in critical care. Anaesthesia 72:560–565
Giamarellos-Bourboulis EJ, Tziolos N, Routsi C, Katsenos C, Tsangaris I, Pneumatikos I, Vlachogiannis G, Theodorou V, Prekates A, Antypa E, Koulouras V, Kapravelos N, Gogos C, Antoniadou E, Mandragos K, Armaganidis A, Hellenic Sepsis Study Group (2016) Improving outcomes of severe infections by multidrug-resistant pathogens with polyclonal IgM-enriched immunoglobulins. Clin Microbiol Infect 22:499–506
Ishikura H, Nakamura Y, Kawano Y, Tanaka J, Mizunuma M, Ohta D, Nishida T, Murai A (2015) Intravenous immunoglobulin improves sepsis-induced coagulopathy: a retrospective, single-center observational study. J Crit Care 30:579–583
Acknowledgements
Dr. Shankar-Hari is supported by the National Institute for Health Research Clinician Scientist Award (CS-2016-16-011). Dr. Turgeon is the Canada Research Chair in Critical Care Neurology and Trauma and is supported by the Canadian Institutes of Health Research. The views expressed in this publication are those of the author(s) and not necessarily those of the NHS, the National Institute for Health Research or the Department of Health.
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All authors developed the outline. MSH wrote the first draft. All authors contributed to the critical revision of the manuscript for important intellectual content.
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The Department of Intensive Care, Rigshospitalet, receives support for research from CSL Behring, Ferring Pharmaceuticals and Fresenius Kabi. MS-H’s department acknowledges receipt of honoraria from Biotest for two talks MSH given at meetings.
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Shankar-Hari, M., Madsen, M.B. & Turgeon, A.F. Immunoglobulins and sepsis. Intensive Care Med 44, 1923–1925 (2018). https://doi.org/10.1007/s00134-018-5047-6
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DOI: https://doi.org/10.1007/s00134-018-5047-6