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Zoledronic acid

Treatment option for Gorham-Stout disease

Zoledronsäure

Behandlungsoption für das Gorham-Stout-Syndrom

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Abstract

Gorham-Stout disease is a rare bone resorption disease, the etiology and prognosis of which is uncertain but it is thought to be benign. It can involve one or more bones and can cause pain, swelling, deformity and fractures in affected bones. Diagnosis is made with a combination of clinical, radiological and histopathological examinations once other causes of osteolysis have been excluded. Due to its rarity, there is no standard therapeutic approach.

Zusammenfassung

Das Gorham-Stout-Syndrom ist eine seltene Erkrankung, bei der es zu einem Knochenabbau kommt. Ätiologie und Prognose sind ungewiss, aber es gilt als benigne. Es kann ein oder mehrere Knochen betreffen, dabei kann es zu Schmerzen, Schwellungen, Deformitäten und Frakturen in den betroffenen Knochen kommen. Die Diagnose wird anhand einer Kombination aus klinischen, radiologischen und histopathologischen Untersuchungen gestellt, sofern andere Ursachen für die Osteolyse ausgeschlossen wurden. Aufgrund seiner Seltenheit gibt es keine Standardtherapie für diese Erkrankung.

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Abbreviations

ALP:

Alkaline phosphatase

AP:

Anteroposterior

CT:

Computed tomography

GSD:

Gorham-Stout disease

MM:

Multiple myeloma

PET-CT:

Positron emission tomography-CT

PTH:

Parathyroid hormone

VEGF:

Vascular endothelial growth factor

ZA:

Zoledronic acid

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Authors and Affiliations

  1. Fatih Sultan Mehmet Training and Research Hospital, Department of Physical Medicine and Rehabilitation, University of Health Sciences, 34752, Istanbul, Turkey

    Ozge Gulsum Illeez, Feyza Unlu Ozkan & Ilknur Aktas

  2. Faculty of Medicine, Göztepe Training and Research Hospital, Department of Orthopaedics and Traumatology, Istanbul Medeniyet University, 34722, Istanbul, Turkey

    Korhan Ozkan, Ali Burak Bostan & Fuat Akpinar

  3. Istanbul Faculty of Medicine, Department of Pathology, Istanbul University, 34093, Istanbul, Turkey

    Bilge Bilgic

Authors
  1. Ozge Gulsum Illeez
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  2. Korhan Ozkan
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  3. Feyza Unlu Ozkan
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  4. Ali Burak Bostan
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  5. Fuat Akpinar
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  6. Bilge Bilgic
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  7. Ilknur Aktas
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Correspondence to Ozge Gulsum Illeez.

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Conflict of interest

O.G. Illeez, K. Ozkan, F.U. Ozkan, A.B. Bostan, F. Akpinar, B. Bilgic and I. Aktas declare that they have no competing interests.

This article does not contain any studies with human participants or animals performed by any of the authors. For images or other information within the manuscript which identify patients, consent was obtained from them and/or their legal guardians.

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Illeez, O.G., Ozkan, K., Ozkan, F.U. et al. Zoledronic acid. Orthopäde 47, 1032–1035 (2018). https://doi.org/10.1007/s00132-018-3655-z

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  • DOI: https://doi.org/10.1007/s00132-018-3655-z

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