Zusammenfassung
Multiple Faktoren können die Ausbildung einer Pseudarthrose und ein Konstruktversagen nach lumbaler Pedikelsubtraktionsosteotomie (PSO) begünstigen und in den meisten Fällen sind mehrere Faktoren gemeinsam ausschlaggebend. Diese Arbeit versucht, die chirurgischen, biomechanischen und biologischen Aspekte zu erklären, die verstanden werden sollten, um das Risiko für Pseudarthrosen und Konstruktversagen zu minimieren. Es werden technische Varianten der PSO und chirurgisch-technische Aspekte dargestellt sowie die Wahl von Metalllegierungen und Multistabkonstrukte erklärt. Biologische Gründe für eine Pseudarthrose und Vermeidungsstrategien werden ebenso diskutiert wie der mögliche Einfluss von Low-grade-Infekten auf die Pseudarthroseentstehung. Zudem wird auf indikatorische Aspekte eingegangen und auf die mögliche Alternative, Lordosen über multiple ALIF zu rekonstruieren, um so unter Umständen eine PSO zu vermeiden.
Abstract
There are numerous factors that can lead to construct failure and pseudarthrosis after corrective pedicle subtraction osteotomy (PSO) in the lumbar spine. Frequently, several factors are of relevance in these problematic cases. This article attempts to explain the surgical, biomechanical and biological aspects that should be understood in order to minimize the risk of pseudarthrosis and construct failure. It addresses technical varieties of the PSO procedure as well as the surgical technique, the choice of rod material and the design of multirod constructs. Biological reasons for pseudarthrosis and preventive strategies are discussed, as well as the possible contribution of low-grade infections to pseudarthrosis. The option of substituting a multilevel ALIF procedure for a PSO is another topic, as is the question of surgical indication and strategy.
Abbreviations
- ALIF:
-
„Anterior lumbar interbody fusion“
- ASD :
-
Adulte spinale Deformitäten
- CAM:
-
Mitte der Verbindungslinie zwischen den Meati acustici
- CoCr:
-
„Cobalt chrome“
- CPTi :
-
„Commercially pure titanium“
- LWS :
-
Lendenwirbelsäule
- oPLIF :
-
„Open posterior lumbar intervertebral fusion“
- PI :
-
„Pelvic incidence“
- PLIF :
-
„Posterior lumbar intervertebral fusion“
- PMMA :
-
Polymethylmethacrylat
- PSO :
-
Pedikelsubtraktionsosteotomie
- rhBMP :
-
Rekombinantes menschliches Knochenmorphogeneseprotein
- SS :
-
„Stainless steel“
- SVA :
-
Sagittale vertikale Achse
- TiAlV :
-
Titanium-alumin(i)um-vanadium
- TLIF :
-
„Transforaminal lumbar interbody fusion“
- XLIF :
-
„Extreme lateral interbody fusion“
- Z. n.:
-
Zustand nach
Literatur
Ames CP, Barry JJ, Keshavarzi S, Dede O, Weber MH, Deviren V (2013) Perioperative Outcomes and Complications of Pedicle Subtraction Osteotomy in Cases With Single Versus Two Attending Surgeons. Spine Deform 1:51–58. https://doi.org/10.1016/j.jspd.2012.10.004
Hyun SJ, Rhim SC (2010) Clinical outcomes and complications after pedicle subtraction osteotomy for fixed sagittal imbalance patients : a long-term follow-up data. J Korean Neurosurg Soc 47:95–101. https://doi.org/10.3340/jkns.2010.47.2.95
Auerbach JD, Lenke LG, Bridwell KH, Sehn JK, Milby AH, Bumpass D, Crawford CH 3rd, O’Shaughnessy BA, Buchowski JM, Chang MS, Zebala LP, Sides BA (2012) Major complications and comparison between 3‑column osteotomy techniques in 105 consecutive spinal deformity procedures. Spine (Phila Pa 1976) 37, S 1198–1210 https://doi.org/10.1097/BRS.0b013e31824fffde
Smith JS, Shaffrey CI, Ames CP, Demakakos J, Fu KM, Keshavarzi S, Li CM, Deviren V, Schwab FJ, Lafage V, Bess S (2012) Assessment of symptomatic rod fracture after posterior instrumented fusion for adult spinal deformity. Neurosurgery 71:862–867. https://doi.org/10.1227/NEU.0b013e3182672aab
Gangnet N, Pomero V, Dumas R, Skalli W, Vital JM (2003) Variability of the spine and pelvis location with respect to the gravity line: a three-dimensional stereoradiographic study using a force platform. Surgical and radiologic anatomy. SRA 25:424–433. https://doi.org/10.1007/s00276-003-0154-6
Hasegawa K, Okamoto M, Hatsushikano S, Shimoda H, Ono M, Watanabe K (2016) Normative values of spino-pelvic sagittal alignment, balance, age, and health-related quality of life in a cohort of healthy adult subjects. Eur Spine J 25:3675–3686. https://doi.org/10.1007/s00586-016-4702-2
Steffen JS, Obeid I, Aurouer N, Hauger O, Vital JM, Dubousset J, Skalli W (2010) 3D postural balance with regard to gravity line: an evaluation in the transversal plane on 93 patients and 23 asymptomatic volunteers. Eur Spine J 19:760–767. https://doi.org/10.1007/s00586-009-1249-5
Barton C, Noshchenko A, Patel V, Cain C, Kleck C, Burger E (2015) Risk factors for rod fracture after posterior correction of adult spinal deformity with osteotomy: a retrospective case-series. Scoliosis 10:30. https://doi.org/10.1186/s13013-015-0056-5
Kim YJ, Bridwell KH, Lenke LG, Cheh G, Baldus C (2007) Results of lumbar pedicle subtraction osteotomies for fixed sagittal imbalance: a minimum 5‑year follow-up study. Spine (Phila Pa 1976) 32:2189–2197. https://doi.org/10.1097/BRS.0b013e31814b8371. 00007632-200709150-00008 [pii]
Dickson DD, Lenke LG, Bridwell KH, Koester LA (2014) Risk factors for and assessment of symptomatic pseudarthrosis after lumbar pedicle subtraction osteotomy in adult spinal deformity. Spine (Phila Pa 1976) 39, S 1190–1195 https://doi.org/10.1097/BRS.0000000000000380
Luca A, Lovi A, Galbusera F, Brayda-Bruno M (2014) Revision surgery after PSO failure with rod breakage: a comparison of different techniques. Eur Spine J 23 Suppl 6:610–615. https://doi.org/10.1007/s00586-014-3555-9
Dorward IG, Lenke LG, Bridwell KH, O’Leary PT, Stoker GE, Pahys JM, Kang MM, Sides BA, Koester LA (2013) Transforaminal versus anterior lumbar interbody fusion in long deformity constructs: a matched cohort analysis. Spine (Phila Pa 1976) 38:E755–762. https://doi.org/10.1097/BRS.0b013e31828d6ca3
Chang KW, Cheng CW, Chen HC, Chang KI, Chen TC (2008) Closing-opening wedge osteotomy for the treatment of sagittal imbalance. Spine (Phila Pa 1976) 33:1470–1477. doi: https://doi.org/10.1097/BRS.0b013e3181753bcd. 00007632-200806010-00013 [pii]
Varga PP, Jakab G, Bors IB, Lazary A, Szoverfi Z (2015) Experiences with PMMA cement as a stand-alone intervertebral spacer. Percutaneous cement discoplasty in the case of vacuum phenomenon within lumbar intervertebral discs. Orthopäde 44:124–131. https://doi.org/10.1007/s00132-015-3092-1
Leveque JC, Yanamadala V, Buchlak QD, Sethi RK (2017) Correction of severe spinopelvic mismatch: decreased blood loss with lateral hyperlordotic interbody grafts as compared with pedicle subtraction osteotomy. Neurosurg Focus 43:E15. https://doi.org/10.3171/2017.5.focus17195
Strom RG, Bae J, Mizutani J, Valone F 3rd, Ames CP, Deviren V (2016) Lateral interbody fusion combined with open posterior surgery for adult spinal deformity. J Neurosurg Spine 25:697–705. https://doi.org/10.3171/2016.4.spine16157
Mundis GM Jr., Turner JD, Kabirian N, Pawelek J, Eastlack RK, Uribe J, Klineberg E, Bess S, Ames C, Deviren V, Nguyen S, Lafage V, Akbarnia BA (2017) Anterior Column Realignment has Similar Results to Pedicle Subtraction Osteotomy in Treating Adults with Sagittal Plane Deformity. World neurosurgery https://doi.org/10.1016/j.wneu.2017.05.122
Thomasen E (1985) Vertebral osteotomy for correction of kyphosis in ankylosing spondylitis. Clin Orthop Relat Res 194:142–152
Reyle G, Lorbach O, Diffo Kaze A, Hoffmann A, Pape D (2017) Prevention of lateral cortex fractures in open wedge high tibial osteotomies : The anteroposterior drill hole approach. Orthopäde 46:610–616. https://doi.org/10.1007/s00132-017-3418-2
Charosky S, Moreno P, Maxy P (2014) Instability and instrumentation failures after a PSO: a finite element analysis. Eur Spine J 23:2340–2349. https://doi.org/10.1007/s00586-014-3295-x
Luca A, Ottardi C, Lovi A, Brayda-Bruno M, Villa T, Galbusera F (2017) Anterior support reduces the stresses on the posterior instrumentation after pedicle subtraction osteotomy: a finite-element study. Eur Spine J. https://doi.org/10.1007/s00586-017-5084-9
Boachie-Adjei O (2006) Role and technique of eggshell osteotomies and vertebral column resections in the treatment of fixed sagittal imbalance. Instr Course Lect 55:583–589
Enercan M, Ozturk C, Kahraman S, Sarier M, Hamzaoglu A, Alanay A (2013) Osteotomies/spinal column resections in adult deformity. Eur Spine J 22 Suppl 2:S254–264. https://doi.org/10.1007/s00586-012-2313-0
Schwab F, Blondel B, Chay E, Demakakos J, Lenke L, Tropiano P, Ames C, Smith JS, Shaffrey CI, Glassman S, Farcy JP, Lafage V (2014) The comprehensive anatomical spinal osteotomy classification. Neurosurgery 74:112–120
Berjano P, Pejrona M, Damilano M, Cecchinato R, Aguirre MF, Lamartina C (2015) Corner osteotomy: a modified pedicle subtraction osteotomy for increased sagittal correction in the lumbar spine. Eur Spine J 24 Suppl 1:58–65. https://doi.org/10.1007/s00586-014-3618-y
Tang JA, Leasure JM, Smith JS, Buckley JM, Kondrashov D, Ames CP (2013) Effect of severity of rod contour on posterior rod failure in the setting of lumbar pedicle subtraction osteotomy (PSO): a biomechanical study. Neurosurgery 72:276–282
Nguyen TQ, Buckley JM, Ames C, Deviren V (2011) The fatigue life of contoured cobalt chrome posterior spinal fusion rods. Proc Inst Mech Eng H 225:194–198
Luca A, Ottardi C, Sasso M, Prosdocimo L, La Barbera L, Brayda-Bruno M, Galbusera F, Villa T (2017) Instrumentation failure following pedicle subtraction osteotomy: the role of rod material, diameter, and multi-rod constructs. Eur Spine J 26:764–770. https://doi.org/10.1007/s00586-016-4859-8
Jager ZS, Inceoglu S, Palmer D, Akpolat YT, Cheng WK (2016) Preventing Instrumentation Failure in Three-Column Spinal Osteotomy: Biomechanical Analysis of Rod Configuration. Spine Deform 4:3–9. https://doi.org/10.1016/j.jspd.2015.06.005
Hyun SJ, Lenke LG, Kim YC, Koester LA, Blanke KM (2014) Comparison of standard 2‑rod constructs to multiple-rod constructs for fixation across 3‑column spinal osteotomies. Spine (Phila Pa 1976) 39, S 1899–1904 https://doi.org/10.1097/brs.0000000000000556
Kavadi N, Tallarico RA, Lavelle WF (2017) Analysis of instrumentation failures after three column osteotomies of the spine. Scoliosis Spinal Disord 12:19. https://doi.org/10.1186/s13013-017-0127-x
Ebata S, Takahashi J, Hasegawa T, Mukaiyama K, Isogai Y, Ohba T, Shibata Y, Ojima T, Yamagata Z, Matsuyama Y, Haro H (2017) Role of Weekly Teriparatide Administration in Osseous Union Enhancement within Six Months After Posterior or Transforaminal Lumbar Interbody Fusion for Osteoporosis-Associated Lumbar Degenerative Disorders: A Multicenter, Prospective Randomized Study. J Bone Joint Surg Am 99:365–372. https://doi.org/10.2106/JBJS.16.00230
Sugiura T, Kashii M, Matsuo Y, Morimoto T, Honda H, Kaito T, Iwasaki M, Yoshikawa H (2015) Intermittent administration of teriparatide enhances graft bone healing and accelerates spinal fusion in rats with glucocorticoid-induced osteoporosis. Spine J 15:298–306. https://doi.org/10.1016/j.spinee.2014.08.001
Ohtori S, Inoue G, Orita S, Yamauchi K, Eguchi Y, Ochiai N, Kishida S, Kuniyoshi K, Aoki Y, Nakamura J, Ishikawa T, Miyagi M, Kamoda H, Suzuki M, Kubota G, Sakuma Y, Oikawa Y, Inage K, Sainoh T, Takaso M, Ozawa T, Takahashi K, Toyone T (2012) Teriparatide accelerates lumbar posterolateral fusion in women with postmenopausal osteoporosis: prospective study. Spine (Phila Pa 1976) 37:E1464–1468. https://doi.org/10.1097/BRS.0b013e31826ca2a8
Inoue G, Ueno M, Nakazawa T, Imura T, Saito W, Uchida K, Ohtori S, Toyone T, Takahira N, Takaso M (2014) Teriparatide increases the insertional torque of pedicle screws during fusion surgery in patients with postmenopausal osteoporosis. J Neurosurg Spine 21:425–431. https://doi.org/10.3171/2014.5.spine13656
Ohtori S, Inoue G, Orita S, Yamauchi K, Eguchi Y, Ochiai N, Kishida S, Kuniyoshi K, Aoki Y, Nakamura J, Ishikawa T, Miyagi M, Kamoda H, Suzuki M, Kubota G, Sakuma Y, Oikawa Y, Inage K, Sainoh T, Takaso M, Toyone T, Takahashi K (2013) Comparison of teriparatide and bisphosphonate treatment to reduce pedicle screw loosening after lumbar spinal fusion surgery in postmenopausal women with osteoporosis from a bone quality perspective. Spine (Phila Pa 1976) 38:E487–492. https://doi.org/10.1097/BRS.0b013e31828826dd
Cho PG, Ji GY, Shin DA, Ha Y, Yoon DH, Kim KN (2015) An effect comparison of teriparatide and bisphosphonate on posterior lumbar interbody fusion in patients with osteoporosis: a prospective cohort study and preliminary data. Eur Spine J. https://doi.org/10.1007/s00586-015-4342-y
Vavken J, Mameghani A, Vavken P, Schaeren S (2016) Complications and cancer rates in spine fusion with recombinant human bone morphogenetic protein-2 (rhBMP-2). Eur Spine J 25:3979–3989. https://doi.org/10.1007/s00586-015-3870-9
Bannwarth M, Kleiber JC, Marlier B, Eap C, Duntze J, Litre CF (2016) Ectopic bone formation with joint impingement after posterior lumbar fusion with rhBMP-2. Orthopaedics & traumatology, surgery & research. OTSR 102:255–256. https://doi.org/10.1016/j.otsr.2015.11.013
Aichmair A, Girardi FP, Hughes AP, Sama AA, Lebl DR, Cammisa FP (2013) Symptomatic heterotopic bone formation after rhBMP-2 utilization in lateral lumbar interbody fusion. Spine J 13:1411–1412. https://doi.org/10.1016/j.spinee.2013.07.473
Lehman RA Jr., Kang DG (2012) Symptomatic ectopic intracanal ossification after transforaminal lumbar interbody fusion with rhBMP-2. Spine J 12:530–531. https://doi.org/10.1016/j.spinee.2012.05.005
Glassman SD, Howard J, Dimar J, Sweet A, Wilson G, Carreon L (2011) Complications with recombinant human bone morphogenic protein-2 in posterolateral spine fusion: a consecutive series of 1037 cases. Spine (Phila Pa 1976) 36:1849–1854. https://doi.org/10.1097/BRS.0b013e3181d133d0
Newman JH, Mitchell RG (1975) Diphtheroid infection of the cervical spine. Acta Orthop Scand 46:67–70
Richards BS (1995) Delayed infections following posterior spinal instrumentation for the treatment of idiopathic scoliosis. J Bone Joint Surg Am 77:524–529
Stirling A, Worthington T, Rafiq M, Lambert PA, Elliott TS (2001) Association between sciatica and Propionibacterium acnes. Lancet 357:2024–2025. https://doi.org/10.1016/S0140-6736(00)05109-6
Albert HB, Sorensen JS, Christensen BS, Manniche C (2013) Antibiotic treatment in patients with chronic low back pain and vertebral bone edema (Modic type 1 changes): a double-blind randomized clinical controlled trial of efficacy. Eur Spine J 22:697–707. https://doi.org/10.1007/s00586-013-2675-y
Albert HB, Lambert P, Rollason J, Sorensen JS, Worthington T, Pedersen MB, Norgaard HS, Vernallis A, Busch F, Manniche C, Elliott T (2013) Does nuclear tissue infected with bacteria following disc herniations lead to Modic changes in the adjacent vertebrae? Eur Spine J 22:690–696. https://doi.org/10.1007/s00586-013-2674-z
Birkenmaier C (2013) Should We Start Treating Chronic Low Back Pain with Antibiotics Rather than with Pain Medications? Korean J Pain 26:327–335. https://doi.org/10.3344/kjp.2013.26.4.327
Capoor MN, Ruzicka F, Schmitz JE, James GA, Machackova T, Jancalek R, Smrcka M, Lipina R, Ahmed FS, Alamin TF, Anand N, Baird JC, Bhatia N, Demir-Deviren S, Eastlack RK, Fisher S, Garfin SR, Gogia JS, Gokaslan ZL, Kuo CC, Lee YP, Mavrommatis K, Michu E, Noskova H, Raz A, Sana J, Shamie AN, Stewart PS, Stonemetz JL, Wang JC, Witham TF, Coscia MF, Birkenmaier C, Fischetti VA, Slaby O (2017) Propionibacterium acnes biofilm is present in intervertebral discs of patients undergoing microdiscectomy. PLoS ONE 12:e174518. https://doi.org/10.1371/journal.pone.0174518
Capoor MN, Ruzicka F, Machackova T, Jancalek R, Smrcka M, Schmitz JE, Hermanova M, Sana J, Michu E, Baird JC, Ahmed FS, Maca K, Lipina R, Alamin TF, Coscia MF, Stonemetz JL, Witham T, Ehrlich GD, Gokaslan ZL, Mavrommatis K, Birkenmaier C, Fischetti VA, Slaby O (2016) Prevalence of Propionibacterium acnes in Intervertebral Discs of Patients Undergoing Lumbar Microdiscectomy: A Prospective Cross-Sectional Study. PLoS ONE 11:e161676. https://doi.org/10.1371/journal.pone.0161676
Shifflett GD, Bjerke-Kroll BT, Nwachukwu BU, Kueper J, Burket J, Sama AA, Girardi FP, Cammisa FP, Hughes AP (2016) Microbiologic profile of infections in presumed aseptic revision spine surgery. Eur Spine J 25:3902–3907. https://doi.org/10.1007/s00586-016-4539-8
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Interessenkonflikt
C. Birkenmaier gibt an, dass kein Interessenkonflikt besteht.
Dieser Beitrag beinhaltet keine von den Autoren durchgeführten Studien an Menschen oder Tieren.
Rights and permissions
About this article
Cite this article
Birkenmaier, C. Pseudarthrose und Konstruktversagen nach lumbaler Pedikelsubtraktionsosteotomie. Orthopäde 47, 310–319 (2018). https://doi.org/10.1007/s00132-018-3537-4
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00132-018-3537-4