Zusammenfassung
Die Schwangerschaft stellt die einzigartige Situation dar, in der 2 allogene Organismen, Mutter und Fetus, ohne Abstoßungsreaktionen in Symbiose zusammenleben. Die Plazenta bildet dabei den größten Teil der Grenzfläche und ist somit von besonderer immunologischer Bedeutung. Verschiedenste plazentare Faktoren, großenteils von Trophoblastzellen produziert und sezerniert, induzieren eine weitgehend spezifische Toleranz gegenüber dem Embryo oder Fetus, ohne dabei die eigentlichen Funktionen des Immunsystems grundlegend zu verändern. Störungen dieser Toleranz können zu allen Zeitpunkten den Schwangerschaftsverlauf beeinträchtigen oder eine Schwangerschaft gar nicht erst zustande kommen lassen. Immunologische Parameter im Endometrium haben daher das Potenzial, als diagnostische Marker und für neue Behandlungsstrategien bei Kinderwunschpatientinnen genutzt zu werden. Die vorliegende Übersichtsarbeit soll einen groben Eindruck in die komplexe Thematik vermitteln.
Abstract
Pregnancy is the unique situation in which two allogeneic organisms, mother and fetus, live in symbiosis without rejection. The placenta forms the major part of the interface, and therefore, plays a special immunological role. Very different placental factors, mainly produced and secreted by trophoblast cells, induce a widely specific tolerance towards the embryo and fetus without major alterations of the principle functions of the immune system. At any time, disorders of this tolerance may harm pregnancy or even inhibit its initiation by disturbing implantation and placentation. Immunological parameters in the endometrium have the potential of serving as diagnostic markers or for developing novel treatment strategies in infertile patients. The present review aims to provide a rough overview on this complex topic.
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U.R. Markert, J. Seitz, T. Wagner, J. Götze, S. Schamberger, J.I. Heger und J. Pastuschek geben an, dass kein Interessenkonflikt besteht.
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Markert, U.R., Seitz, J., Wagner, T. et al. Pathophysiologie der Frühschwangerschaft, Plazentation und Immunologie. Gynäkologe 51, 274–285 (2018). https://doi.org/10.1007/s00129-018-4228-2
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DOI: https://doi.org/10.1007/s00129-018-4228-2