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Impact of Metal Toxicity on Oxidative Balance and Mitochondrial Enzyme Function in Muscle of Tilapia

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Abstract

Present study investigates the effect of metal accumulation on antioxidant level and mitochondrial enzymes function in muscle of Oreochromis mossambicus. Metal accumulation in muscle upregulated stress marker malondialdehyde and the activity of different antioxidant enzymes with no significant alteration in glutathione system. Metal exposure to fish muscle decreased the activity of mitochondrial enzymes. AMP deaminase, aldolase, cytochrome C oxidase and lipoamide reductase showed positive correlation with acetylcholinesterase, glutathione reductase, reduced glutathione and glutathione peroxidase, but negative correlation with superoxide dismutase, catalase, glutathione S-transferase and thiobarbituric acid reactive substance. Analysis of these biomarkers clearly indicates the change in oxidative load in muscle tissues and provides insight to muscle response to the metal exposure. Therefore, the study outlines the potential use of biomarkers in context of muscle mitochondrial enzymes relating to oxidative processes that take place in the fish muscle following metal exposure and toxicity.

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Acknowledgements

Financial assistance from the Department of Environment (Sanction No. 1884/EN/P/T-VIII-2/029/2013), Government of West Bengal, West Bengal, India, is thankfully acknowledged. MM thankfully acknowledging DBT Research Associateship Programme, Govt. of India, IISC, Bangalore, for financial support.

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Authors and Affiliations

  1. Department of Zoology, University of Calcutta, 35 Ballygunge Circular Road, Kolkata, West Bengal, 700019, India

    Debjit Das, Mahammed Moniruzzaman, Samya Karan & Suman Bhusan Chakraborty

  2. Department of Statistics, Visva-Bharati University, Santiniketan, West Bengal, India

    Soumalya Mukhopadhyay

  3. Department of Zoology, Surendranath College, Kolkata, India

    Adity Sarbajna

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  1. Debjit Das
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  2. Mahammed Moniruzzaman
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  3. Soumalya Mukhopadhyay
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  4. Samya Karan
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  5. Adity Sarbajna
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  6. Suman Bhusan Chakraborty
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Correspondence to Suman Bhusan Chakraborty.

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Das, D., Moniruzzaman, M., Mukhopadhyay, S. et al. Impact of Metal Toxicity on Oxidative Balance and Mitochondrial Enzyme Function in Muscle of Tilapia. Bull Environ Contam Toxicol 100, 647–652 (2018). https://doi.org/10.1007/s00128-018-2303-y

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  • DOI: https://doi.org/10.1007/s00128-018-2303-y

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