Tissue-Specific Antioxidative Responses and Cadmium Accumulation in Silurus meridionalis Under Chronic Waterborne Cadmium Exposure

Article

Abstract

In this study, the oxidative damage, antioxidative responses and cadmium (Cd) accumulation in juvenile Silurus meridionalis were studied, after S. meridionalis were exposed to 0 (control), 62.5, 125, 250 and 500 µg Cd/L for 56 days. Cd accumulation, malondialdehyde, superoxide dismutase (SOD), catalase, glutathione (GSH) and total antioxidant capacity (T-AOC) were determined in gill, liver, kidney and intestine tissues. The results showed that the Cd accumulation in S. meridionalis was dose-dependent and tissue-specific, with the highest Cd content in the kidney, followed by the liver, gill, and intestine. Waterborne Cd stress in S. meridionalis was expressed as tissue-specific oxidative damage and antioxidant responses in gill, liver, kidney and intestine tissues. Waterborne Cd exposure induced the most significant oxidative damage in the gill, followed by the liver and kidney, while the intestine showed no sensitivity to waterborne Cd exposure. The antioxidants, such as SOD in the liver, kidney and intestine, as well as T-AOC and GSH in the gill, liver and kidney, were sensitive to waterborne Cd exposure.

Keywords

Waterborne Cd exposure Silurus meridionalis Oxidative damage Antioxidative responses 

Notes

Acknowledgements

This work was supported by the Natural Science Foundation of Chongqing (No. cstc2013jjB80008), the Fundamental Research Funds for the Central Universities (No. XDJK2016C156), the Start-up Research Grant from Qinzhou University (No. 2017KYQD107) and the Research Funds from Guangxi Key Laboratory of Beibu Gulf Marine Biodiversity Conservation (No. 2018ZB03).

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Authors and Affiliations

  1. 1.Guangxi Key Laboratory of Beibu Gulf Marine Biodiversity Conservation, Ocean CollegeQinzhou UniversityQinzhouChina
  2. 2.Key Laboratory of Freshwater Fish Reproduction and Development (Ministry of Education), Institute of Hydrobiology and Water Environment, School of Life SciencesSouthwest UniversityChongqingChina

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