Table 2  Effect of MSC-exosomes on hyperglycaemia, lipids and body weight

From: Mesenchymal stromal cell-derived exosomes ameliorate peripheral neuropathy in a mouse model of diabetes

Feature db/mdb/dbdb + exo
Body weight (g)0 weeks30.0 ± 0.953.3 ± 6.6††54.3 ± 6.5††
8 weeks33.0 ± 1.854.5 ± 7.8††53.2 ± 8.3††
Blood glucose (mmol/l)0 weeks7.2 ± 0.928.4 ± 2.3†††29.1 ± 2.1†††
8 weeks7.1 ± 0.927.9 ± 1.9†††26.6 ± 2.6†††
HbA1c (mmol/mol)0 weeks22.1 ± 1.589.1 ± 15.1†††85.8 ± 11.6†††
HbA1c (%)4.2 ± 0.110.3 ± 2.1†††10.0 ± 1.1†††
HbA1c (mmol/mol)8 weeks22.6 ± 3.1101.1 ± 19.6†††94.5 ± 14.2†††
HbA1c (%)4.4 ± 0.311.4 ± 2.7†††10.8 ± 2.1†††
Total cholesterol (mmol/l)0 weeks2.2 ± 0.23.8 ± 0.3†††3.9 ± 0.3†††
8 weeks2.3 ± 0.24.3 ± 0.3†††4.1 ± 0.2†††
Triacylglycerol (mmol/l)0 weeks0.6 ± 0.10.9 ± 0.1††0.9 ± 0.1††
8 weeks0.6 ± 0.11.0 ± 0.1††1.0 ± 0.1††
Serum insulin (pmol/l)0 weeks121.0 ± 27.5315.0 ± 44.0†††307.0 ± 34.4†††
8 weeks165.0 ± 28.2330.0 ± 24.0†††319.0 ± 31.5†††
  1. Values are mean ± SEM; n = 8/group
  2. ††p < 0.01, †††p < 0.001 vs db/m group
  3. The p values are from two-tailed Student’s t test