Mesenchymal stromal cell-derived exosomes ameliorate peripheral neuropathy in a mouse model of diabetes

Table 1 Effect of MSC-exosomes on morphometric changes of myelinated sciatic nerves

Property	db/m	db/db	db + exo
Fibre density (/mm²)	13,060 ± 1363	9361 ± 911^†††	11,058 ± 975^***
Density of myelinated fibres (/mm²)	10,420 ± 792	6829 ± 364^†††	7140 ± 477^***
Density of non-myelinated fibres (/mm²)	2905 ± 630	664 ± 496^†††	922 ± 552^**
Fibre diameter (μm)	8.60 ± 0.3	7.25 ± 0.13^††	8.08 ± 0.13^**
Axon diameter (μm)	5.00 ± 0.11	4.44 ± 0.08^††	4.66 ± 0.05^**
Myelin thickness (μm)	1.71 ± 0.05	1.40 ± 0.03^††	1.62 ± 0.06^*
g-ratio	0.59 ± 0.01	0.63 ± 0.01^†	0.60 ± 0.01^*

Values are mean ± SEM; n = 5/group
^†p < 0.05, ^††p < 0.01, ^†††p < 0.001 vs db/m group; * p < 0.05, **p < 0.01, *** p < 0.001 vs db/db group
The p values are calculated from two-tailed Student’s t test