Table 1 Effect of MSC-exosomes on morphometric changes of myelinated sciatic nerves

From: Mesenchymal stromal cell-derived exosomes ameliorate peripheral neuropathy in a mouse model of diabetes

Propertydb/mdb/dbdb + exo
Fibre density (/mm2)13,060 ± 13639361 ± 911†††11,058 ± 975***
Density of myelinated fibres (/mm2)10,420 ± 7926829 ± 364†††7140 ± 477***
Density of non-myelinated fibres (/mm2)2905 ± 630664 ± 496†††922 ± 552**
Fibre diameter (μm)8.60 ± 0.37.25 ± 0.13††8.08 ± 0.13**
Axon diameter (μm)5.00 ± 0.114.44 ± 0.08††4.66 ± 0.05**
Myelin thickness (μm)1.71 ± 0.051.40 ± 0.03††1.62 ± 0.06*
g-ratio0.59 ± 0.010.63 ± 0.010.60 ± 0.01*
  1. Values are mean ± SEM; n = 5/group
  2. p < 0.05, ††p < 0.01, †††p < 0.001 vs db/m group; * p < 0.05, **p < 0.01, *** p < 0.001 vs db/db group
  3. The p values are calculated from two-tailed Student’s t test