Fig. 7 | Diabetologia

Fig. 7

From: Mesenchymal stromal cell-derived exosomes ameliorate peripheral neuropathy in a mouse model of diabetes

Fig. 7

 miRNAs are involved in MSC-exosome-mediated macrophage polarisation. (a) Highly enriched miRNA content in MSC-exosomes. (b) Enriched biological processes for targeted genes of highly expressed miRNAs. (c) Relative miRNA expression in sciatic nerves from the db/db and db + exo groups, relative to the db/m group, set as 1. (d) miRNA–gene interactions were built into a bipartite network. Red lines indicate an inhibitory effect; the blue lines indicate a stimulatory effect; solid lines represent direct effects; dashed lines represent indirect effects. Western blot analysis (e) and quantitative data (f) of relative expression levels of TLR4, IRAK1 and NF-κB p65 in sciatic nerves of mice. Data are mean ± SEM and were analysed by one-way ANOVA with Tukey’s post hoc test (n = 3/group). p < 0.05, ††p < 0.01 db/db vs db/m; **p < 0.01, ***p < 0.001 db/db vs db + exo. db/db, diabetic group treated with saline; db + exo, diabetic group treated with MSC-exosomes; db/m, non-diabetic group

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