Fig. 5 | Diabetologia

Fig. 5

From: Mesenchymal stromal cell-derived exosomes ameliorate peripheral neuropathy in a mouse model of diabetes

Fig. 5

 MSC-exosomes suppress inflammatory response in peripheral nerves. (a) Representative immunofluorescence images of active macrophages (CD68+ cells), TNF-α, NF200 and MBP in sciatic nerves. (b) Quantitative data of CD68+ cells, as in (a). (c) Quantitative data showing co-localisation (yellow) of TNF-α with NF200 and MBP, as in (a). Nuclei are counterstained with DAPI (blue); scale bars, 20 μm. Data are mean ± SEM and were analysed by one-way ANOVA with Tukey’s post hoc test. †††p < 0.001 db/db vs db/m; *p < 0.05, **p < 0.01 db/db vs db + exo. db/db, diabetic group treated with saline; db + exo, diabetic group treated with MSC-exosomes; db/m, non-diabetic group

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