Der Urologe

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Chemotherapieinduzierte Nausea und Emesis

Aktuelle Empfehlungen zur Prophylaxe
Leitthema
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Zusammenfassung

Die chemotherapieinduzierte Nausea und Emesis (CINE) gehören zu den häufigsten Nebenwirkungen der Zytostatikatherapie und stellen bei der Behandlung onkologischer Patienten eine große Herausforderung dar. Eine korrekte, leitliniengerechte antiemetische Prophylaxe ist daher unerlässlich und trägt wesentlich zum Behandlungserfolg bei. Diese Übersichtsarbeit fasst die aktuellen Empfehlungen der „Multinational Association of Supportive Care in Cancer“ (MASCC) und „European Society of Medical Oncology“ (ESMO), der „American Society for Clinical Oncology“ (ASCO), des „National Comprehensive Cancer Network“ (NCCN) sowie der S3-Leitlinie „Supportive Therapie“ vom „Leitlinienprogramm Onkologie“ zur Prophylaxe der CINE verständlich zusammen und soll deren Anwendung in der täglichen Routine erleichtern.

Schlüsselwörter

Antiemetische Therapie Zytostatikatherapie Leitlinien Emetogenität Glukokortikoide 

Abkürzungen

5-HT

5-Hydroxytryptamin (Serotonin)

5-HT3-Rezeptoren

5‑Hydroxytryptamin-3-Rezeptoren

ANS

Antineoplastische Substanz

ASCO

American Society for Clinical Oncology

AUC

„Area under the curve“

AUO

Arbeitsgemeinschaft Urologische Onkologie

BfArM

Bundesinstitut für Arzneimittel und Medizinprodukte

BID

bis in die (lat.: zweimal täglich)

CINE

Chemotherapiebedingte Nausea und Emesis

CYP

Cytochrom P

ESMO

European Society of Medical Oncology

i. v.

intravenös

INR

International Normalized Ratio

MASCC

Multinational Association of Supportive Care in Cancer

MCP

Metoclopramid

NCCN

National Comprehensive Cancer Network

NK1-Rezeptor

Neurokinin-Rezeptor 1

ZNS

Zentrales Nervensystem

Chemotherapy-induced nausea and vomiting

Current recommendations for prophylaxis

Abstract

The chemotherapy-induced nausea and vomiting (CINV) is one of the most frequent side effects in cytostatic therapy and a profound challenge during the therapy of cancer patients. Therefore, standardized guideline-orientated prophylaxis is essential and a fundamental contribution for the success of treatment. This review summarizes the current recommendations for CINV of the Multinational Association of Supportive Care in Cancer (MASCC) and European Society of Medical Oncology (ESMO), the American Society for Clinical Oncology (ASCO), the National Comprehensive Cancer Network (NCCN) and the S3-guideline Supportive Therapie of the Leitlinienprogramm Onkologie and shall facilitate its use in the daily routine.

Keywords

Antiemetics Cytostatics Guidelines Emetogenicity Glucocorticoids 

Notes

Einhaltung ethischer Richtlinien

Interessenkonflikt

E. Storz, J. E. Gschwend und M. Retz geben an, dass kein Interessenkonflikt besteht.

Dieser Beitrag beinhaltet keine von den Autoren durchgeführten Studien an Menschen oder Tieren.

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Copyright information

© Springer Medizin Verlag GmbH, ein Teil von Springer Nature 2018

Authors and Affiliations

  1. 1.Urologische Klinik und Poliklinik, Klinikum rechts der IsarTechnische Universität MünchenMünchenDeutschland

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