Chemotherapieinduzierte Nausea und Emesis
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Zusammenfassung
Die chemotherapieinduzierte Nausea und Emesis (CINE) gehören zu den häufigsten Nebenwirkungen der Zytostatikatherapie und stellen bei der Behandlung onkologischer Patienten eine große Herausforderung dar. Eine korrekte, leitliniengerechte antiemetische Prophylaxe ist daher unerlässlich und trägt wesentlich zum Behandlungserfolg bei. Diese Übersichtsarbeit fasst die aktuellen Empfehlungen der „Multinational Association of Supportive Care in Cancer“ (MASCC) und „European Society of Medical Oncology“ (ESMO), der „American Society for Clinical Oncology“ (ASCO), des „National Comprehensive Cancer Network“ (NCCN) sowie der S3-Leitlinie „Supportive Therapie“ vom „Leitlinienprogramm Onkologie“ zur Prophylaxe der CINE verständlich zusammen und soll deren Anwendung in der täglichen Routine erleichtern.
Schlüsselwörter
Antiemetische Therapie Zytostatikatherapie Leitlinien Emetogenität GlukokortikoideAbkürzungen
- 5-HT
5-Hydroxytryptamin (Serotonin)
- 5-HT3-Rezeptoren
5‑Hydroxytryptamin-3-Rezeptoren
- ANS
Antineoplastische Substanz
- ASCO
American Society for Clinical Oncology
- AUC
„Area under the curve“
- AUO
Arbeitsgemeinschaft Urologische Onkologie
- BfArM
Bundesinstitut für Arzneimittel und Medizinprodukte
- BID
bis in die (lat.: zweimal täglich)
- CINE
Chemotherapiebedingte Nausea und Emesis
- CYP
Cytochrom P
- ESMO
European Society of Medical Oncology
- i. v.
intravenös
- INR
International Normalized Ratio
- MASCC
Multinational Association of Supportive Care in Cancer
- MCP
Metoclopramid
- NCCN
National Comprehensive Cancer Network
- NK1-Rezeptor
Neurokinin-Rezeptor 1
- ZNS
Zentrales Nervensystem
Chemotherapy-induced nausea and vomiting
Abstract
The chemotherapy-induced nausea and vomiting (CINV) is one of the most frequent side effects in cytostatic therapy and a profound challenge during the therapy of cancer patients. Therefore, standardized guideline-orientated prophylaxis is essential and a fundamental contribution for the success of treatment. This review summarizes the current recommendations for CINV of the Multinational Association of Supportive Care in Cancer (MASCC) and European Society of Medical Oncology (ESMO), the American Society for Clinical Oncology (ASCO), the National Comprehensive Cancer Network (NCCN) and the S3-guideline Supportive Therapie of the Leitlinienprogramm Onkologie and shall facilitate its use in the daily routine.
Keywords
Antiemetics Cytostatics Guidelines Emetogenicity GlucocorticoidsNotes
Einhaltung ethischer Richtlinien
Interessenkonflikt
E. Storz, J. E. Gschwend und M. Retz geben an, dass kein Interessenkonflikt besteht.
Dieser Beitrag beinhaltet keine von den Autoren durchgeführten Studien an Menschen oder Tieren.
Literatur
- 1.AOP (2016) Fachinformation zu CANEMES 1 mg Kaps. http://sr001017043/detailinfo.php?ID=3348522200. Zugegriffen: 02.01.18Google Scholar
- 2.Deutsche Krebsgesellschaft, Deutsche Krebshilfe, AWMF (2017) Leitlinienprogramm Onkologie: S3-Leitlinie Supportive Therapie bei onkologischen PateintInnen, Langversion 1.1, April 2017, AWMF Registrierungsnummer 032/054OL. http://leitlinienprogramm-onkologie.de/. Zugegriffen: 9. Dez. 2017Google Scholar
- 3.Aapro M, Rugo H, Rossi G et al (2014) A randomized phase III study evaluating the efficacy and safety of NEPA, a fixed-dose combination of netupitant and palonosetron, for prevention of chemotherapy-induced nausea and vomiting following moderately emetogenic chemotherapy. Ann Oncol 25:1328–1333CrossRefPubMedPubMedCentralGoogle Scholar
- 4.Aapro MS, Molassiotis A, Olver I (2005) Anticipatory nausea and vomiting. Support Care Cancer 13:117–121CrossRefPubMedGoogle Scholar
- 5.Bymaster FP, Calligaro DO, Falcone JF et al (1996) Radioreceptor binding profile of the atypical antipsychotic olanzapine. Neuropsychopharmacology 14:87–96CrossRefPubMedGoogle Scholar
- 6.Coates A, Abraham S, Kaye SB et al (1983) On the receiving end—patient perception of the side-effects of cancer chemotherapy. Eur J Cancer Clin Oncol 19:203–208CrossRefPubMedGoogle Scholar
- 7.Cohen L, de Moor CA, Eisenberg P et al (2007) Chemotherapy-induced nausea and vomiting: incidence and impact on patient quality of life at community oncology settings. Support Care Cancer 15:497–503CrossRefPubMedGoogle Scholar
- 8.Dando TM, Perry CM (2004) Aprepitant: a review of its use in the prevention of chemotherapy-induced nausea and vomiting. Drugs 64:777–794CrossRefPubMedGoogle Scholar
- 9.Ettinger DS, Berger MJ, Aston J et al (2017) NCCN guidelines; Antiemesis, version 2.2017. http://nccn.org. Zugegriffen: 9. Dez. 2017Google Scholar
- 10.Geling O, Eichler HG (2005) Should 5‑hydroxytryptamine-3 receptor antagonists be administered beyond 24 hours after chemotherapy to prevent delayed emesis? Systematic re-evaluation of clinical evidence and drug cost implications. J Clin Oncol 23:1289–1294CrossRefPubMedGoogle Scholar
- 11.Gralla RJ, Bosnjak SM, Hontsa A et al (2014) A phase III study evaluating the safety and efficacy of NEPA, a fixed-dose combination of netupitant and palonosetron, for prevention of chemotherapy-induced nausea and vomiting over repeated cycles of chemotherapy. Ann Oncol 25:1333–1339CrossRefPubMedPubMedCentralGoogle Scholar
- 12.Gralla RJ, Itri LM, Pisko SE et al (1981) Antiemetic efficacy of high-dose metoclopramide: randomized trials with placebo and prochlorperazine in patients with chemotherapy-induced nausea and vomiting. N Engl J Med 305:905–909CrossRefPubMedGoogle Scholar
- 13.Gralla RJ, Osoba D, Kris MG et al (1999) Recommendations for the use of antiemetics: evidence-based, clinical practice guidelines. American Society of Clinical Oncology. J Clin Oncol 17:2971–2994CrossRefPubMedGoogle Scholar
- 14.Grunberg S, Chua D, Maru A et al (2011) Single-dose fosaprepitant for the prevention of chemotherapy-induced nausea and vomiting associated with cisplatin therapy: randomized, double-blind study protocol–EASE. J Clin Oncol 29:1495–1501CrossRefPubMedGoogle Scholar
- 15.Grunberg SM (2004) Chemotherapy-induced nausea and vomiting: prevention, detection, and treatment—how are we doing? J Support Oncol 2:1–12PubMedGoogle Scholar
- 16.Grunberg SM, Deuson RR, Mavros P et al (2004) Incidence of chemotherapy-induced nausea and emesis after modern antiemetics. Cancer 100:2261–2268CrossRefPubMedGoogle Scholar
- 17.Grunberg SM, Osoba D, Hesketh PJ et al (2005) Evaluation of new antiemetic agents and definition of antineoplastic agent emetogenicity—an update. Support Care Cancer 13:80–84CrossRefPubMedGoogle Scholar
- 18.Hesketh PJ, Aapro M, Street JC et al (2010) Evaluation of risk factors predictive of nausea and vomiting with current standard-of-care antiemetic treatment: analysis of two phase III trials of aprepitant in patients receiving cisplatin-based chemotherapy. Support Care Cancer 18:1171–1177CrossRefPubMedGoogle Scholar
- 19.Hesketh PJ, Grunberg SM, Gralla RJ et al (2003) The oral neurokinin-1 antagonist aprepitant for the prevention of chemotherapy-induced nausea and vomiting: a multinational, randomized, double-blind, placebo-controlled trial in patients receiving high-dose cisplatin–the Aprepitant Protocol 052 Study Group. J Clin Oncol 21:4112–4119CrossRefPubMedGoogle Scholar
- 20.Hesketh PJ, Kris MG, Basch E et al (2017) Antiemetics: American Society of Clinical Oncology clinical practice guideline update. J Clin Oncol 35:3240–3261CrossRefPubMedGoogle Scholar
- 21.Hesketh PJ, Kris MG, Grunberg SM et al (1997) Proposal for classifying the acute emetogenicity of cancer chemotherapy. J Clin Oncol 15:103–109CrossRefPubMedGoogle Scholar
- 22.Jordan K, Gralla R, Jahn F et al (2014) International antiemetic guidelines on chemotherapy induced nausea and vomiting (CINV): content and implementation in daily routine practice. Eur J Pharmacol 722:197–202CrossRefPubMedGoogle Scholar
- 23.Kamen C, Tejani MA, Chandwani K et al (2014) Anticipatory nausea and vomiting due to chemotherapy. Eur J Pharmacol 722:172–179CrossRefPubMedGoogle Scholar
- 24.Licup N (2010) Olanzapine for nausea and vomiting. Am J Hosp Palliat Care 27:432–434CrossRefPubMedGoogle Scholar
- 25.Navari RM (2014) Olanzapine for the prevention and treatment of chronic nausea and chemotherapy-induced nausea and vomiting. Eur J Pharmacol 722:180–186CrossRefPubMedGoogle Scholar
- 26.Navari RM (2015) Profile of netupitant/palonosetron (NEPA) fixed dose combination and its potential in the treatment of chemotherapy-induced nausea and vomiting (CINV). Drug Des Devel Ther 9:155–161PubMedGoogle Scholar
- 27.Navari RM, Einhorn LH, Passik SD et al (2005) A phase II trial of olanzapine for the prevention of chemotherapy-induced nausea and vomiting: a Hoosier Oncology Group study. Support Care Cancer 13:529–534CrossRefPubMedGoogle Scholar
- 28.Navari RM, Gray SE, Kerr AC (2011) Olanzapine versus aprepitant for the prevention of chemotherapy-induced nausea and vomiting: a randomized phase III trial. J Support Oncol 9:188–195CrossRefPubMedGoogle Scholar
- 29.Navari RM, Nagy CK, Gray SE (2013) The use of olanzapine versus metoclopramide for the treatment of breakthrough chemotherapy-induced nausea and vomiting in patients receiving highly emetogenic chemotherapy. Support Care Cancer 21:1655–1663CrossRefPubMedGoogle Scholar
- 30.Perwitasari DA, Gelderblom H, Atthobari J et al (2011) Anti-emetic drugs in oncology: pharmacology and individualization by pharmacogenetics. Int J Clin Pharm 33:33–43CrossRefPubMedPubMedCentralGoogle Scholar
- 31.Poli-Bigelli S, Rodrigues-Pereira J, Carides AD et al (2003) Addition of the neurokinin 1 receptor antagonist aprepitant to standard antiemetic therapy improves control of chemotherapy-induced nausea and vomiting. Results from a randomized, double-blind, placebo-controlled trial in Latin America. Cancer 97:3090–3098CrossRefPubMedGoogle Scholar
- 32.Raftopoulos H, Cooper W, O’Boyle E et al (2015) Comparison of an extended-release formulation of granisetron (APF530) versus palonosetron for the prevention of chemotherapy-induced nausea and vomiting associated with moderately or highly emetogenic chemotherapy: results of a prospective, randomized, double-blind, noninferiority phase 3 trial. Support Care Cancer 23:723–732CrossRefPubMedGoogle Scholar
- 33.Rapoport B, Chua D, Poma A et al (2015) Study of rolapitant, a novel, long-acting, NK-1 receptor antagonist, for the prevention of chemotherapy-induced nausea and vomiting (CINV) due to highly emetogenic chemotherapy (HEC). Support Care Cancer 23:3281–3288CrossRefPubMedGoogle Scholar
- 34.Rapoport BL, Chasen MR, Gridelli C et al (2015) Safety and efficacy of rolapitant for prevention of chemotherapy-induced nausea and vomiting after administration of cisplatin-based highly emetogenic chemotherapy in patients with cancer: two randomised, active-controlled, double-blind, phase 3 trials. Lancet Oncol 16:1079–1089CrossRefPubMedGoogle Scholar
- 35.Rapoport BL, Jordan K, Boice JA et al (2010) Aprepitant for the prevention of chemotherapy-induced nausea and vomiting associated with a broad range of moderately emetogenic chemotherapies and tumor types: a randomized, double-blind study. Support Care Cancer 18:423–431CrossRefPubMedGoogle Scholar
- 36.Roila F, Molassiotis A, Herrstedt J et al (2016) 2016 MASCC and ESMO guideline update for the prevention of chemotherapy- and radiotherapy-induced nausea and vomiting and of nausea and vomiting in advanced cancer patients. Ann Oncol 27(v119):v133Google Scholar
- 37.Schwartzberg L, Barbour SY, Morrow GR et al (2014) Pooled analysis of phase III clinical studies of palonosetron versus ondansetron, dolasetron, and granisetron in the prevention of chemotherapy-induced nausea and vomiting (CINV). Support Care Cancer 22:469–477CrossRefPubMedGoogle Scholar
- 38.Shadle CR, Lee Y, Majumdar AK et al (2004) Evaluation of potential inductive effects of aprepitant on cytochrome P450 3A4 and 2C9 activity. J Clin Pharmacol 44:215–223CrossRefPubMedGoogle Scholar
- 39.Spartinou A, Nyktari V, Papaioannou A (2017) Granisetron: a review of pharmacokinetics and clinical experience in chemotherapy induced—nausea and vomiting. Expert Opin Drug Metab Toxicol 13:1289–1297CrossRefPubMedGoogle Scholar
- 40.Tafelski S, Hauser W, Schafer M (2016) Efficacy, tolerability, and safety of cannabinoids for chemotherapy-induced nausea and vomiting—a systematic review of systematic reviews. Schmerz 30:14–24CrossRefPubMedGoogle Scholar
- 41.Tageja N, Groninger H (2016) Chemotherapy-induced nausea and vomiting: an overview and comparison of three consensus guidelines. Postgrad Med J 92:34–40CrossRefPubMedGoogle Scholar
- 42.Warr D (2014) Prognostic factors for chemotherapy induced nausea and vomiting. Eur J Pharmacol 722:192–196CrossRefPubMedGoogle Scholar