Der Urologe

, Volume 57, Issue 4, pp 391–397 | Cite as

Pathologie und histopathologische Begutachtung des Peniskarzinoms

Leitthema
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Zusammenfassung

Hintergrund

Das Peniskarzinom ist in Deutschland und in den westlichen Industrienationen ein seltener Tumor. Das Wissen über die Pathogenese und die Pathologie dieses Malignoms hat in den letzten Jahren erheblich zugenommen.

Fragestellung

Das klinische Management ist komplexer geworden und organerhaltende Therapiestrategien werden heute bevorzugt. Damit steigt auch die Anforderung an die pathohistologische Begutachtung von Biopsien und Operationspräparaten des Penis.

Material und Methoden

Diese Übersichtsarbeit erläutert auf der Grundlage der Leitlinien und der relevanten Literatur die wichtigsten Aspekte, die bei der Klassifikation und bei der pathohistologischen Befunderstellung des Peniskarzinoms berücksichtigt werden müssen.

Ergebnisse

Die korrekte histologische Subtypisierung des Peniskarzinoms ist wichtig für die Prognose und die Therapieentscheidung. Es gibt auch Besonderheiten in der aktuellen TNM-Klassifikation („tumour, node, metastasis“) dieses Tumors im Vergleich zu anderen Entitäten.

Schlussfolgerungen

Die Bearbeitung der Gewebepräparate und die histopathologische Typisierung erfordern vom Pathologen Kenntnisse der aktuellen Entwicklungen zur Pathogenese, Klassifikation und Therapie des Peniskarzinoms.

Schlüsselwörter

Humane Papillomaviren Neoplasie Vorläuferläsion Malignom Plattenepithelkarzinom 

Pathology and histopathological evaluation of penile cancer

Abstract

Background

Penile cancer is rare in Germany and in western European countries. Our understanding of the pathogenesis and pathology of this malignancy has increased considerably in recent years.

Objectives

Clinical management has become more complex, with organ-preserving strategies being increasingly favored. Associated with these developments, the demands on the pathology reports of biopsies and surgical specimens from the penis have also increased.

Materials and methods

According to guidelines and the relevant literature, this review outlines the most important aspects that must be considered in the classification and pathological reporting of penile cancer.

Results

Correct histological subtyping of penile cancer is important for prognostic and therapeutic considerations. There are also some peculiarities with the current TNM classification system of this tumor compared to other entities.

Conclusion

Handling of specimens and histopathological typing must be performed by experienced pathologists according to recent developments in the pathogenesis, classification, and therapeutic strategies of penile cancer.

Keywords

Human papillomavirus Neoplasms  Precancerous conditions  Malignancy Squamous cell carcinoma 

Notes

Einhaltung ethischer Richtlinien

Interessenkonflikt

A. Erbersdobler gibt an, dass kein Interessenkonflikt besteht.

Dieser Beitrag beinhaltet keine vom Autor durchgeführten Studien an Menschen oder Tieren.

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Copyright information

© Springer Medizin Verlag GmbH, ein Teil von Springer Nature 2018

Authors and Affiliations

  1. 1.Institut für PathologieUniversitätsmedizin RostockRostockDeutschland

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