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Marklagerveränderungen nach Chemotherapie und Bestrahlung

White matter alterations after chemotherapy and radiation

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Zusammenfassung

Heutzutage gehören Chemotherapie und Radiotherapie zu den leitliniengerechten Therapiekonzepten zur Behandlung von malignen Tumoren des Zentralnervensystems. Neurologische Symptome oder bildmorphologische Veränderungen des Marklagers können bei beiden Behandlungsmethoden anhand des zeitlichen Auftretens in akut, subakut und chronisch eingeteilt werden. Sowohl die Symptome als auch die bildmorphologischen Marklagerveränderungen im akuten und subakuten Stadium sind in den meisten Fällen vollständig reversibel. Chronische Leukenzephalopathien können zu ausgeprägten neurologischen Einschränkungen führen und die Lebensqualität von Krebspatienten zusätzlich beeinträchtigen.

Abstract

Nowadays chemotherapy and radiotherapy are fundamental therapy concepts in the guidelines of malignant tumors of the central nervous system. Both therapy concepts can cause neurological symptoms or white matter alterations can occur, which can be classified into acute, subacute and chronic. Both symptoms and white matter alterations during acute and subacute phases are in most cases completely reversible, whereas chronic white matter alterations can lead to severe neurological limitations and further impair the quality of life of cancer patients.

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Authors and Affiliations

  1. Klinik für Diagnostische und Interventionelle Neuroradiologie, Universitätsklinikum des Saarlandes, Kirrberger Str. 1, 66424, Homburg/Saar, Deutschland

    A. Simgen

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A. Simgen gibt an, dass kein Interessenkonflikt besteht.

Alle beschriebenen Untersuchungen am Menschen wurden mit Zustimmung der zuständigen Ethik-Kommission, im Einklang mit nationalem Recht sowie gemäß der Deklaration von Helsinki von 1975 (in der aktuellen, überarbeiteten Fassung) durchgeführt. Von allen beteiligten Patienten liegt eine Einverständniserklärung vor.

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Simgen, A. Marklagerveränderungen nach Chemotherapie und Bestrahlung. Radiologe 58, 1060–1066 (2018). https://doi.org/10.1007/s00117-018-0458-5

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