Zusammenfassung
Der Nachweis subsolider intrapulmonaler Rundherde stellt ein häufiges Problem in der täglichen klinisch-radiologischen Routine dar. Das biologische Verhalten subsolider Rundherde unterscheidet sich wesentlich von soliden intrapulmonalen Rundherden. Das Risiko für Malignität ist für subsolide Rundherde deutlich höher im Vergleich zu soliden oder reinen Milchglasrundherden. Die Empfehlungen für das diagnostische Management subsolider Rundherde wurden entsprechend der Wachstumstendenz sowie des Malignitätsrisikos adaptiert. Eine benigne Ätiologie ist bei subsoliden Rundherden ebenfalls oft zu finden. Diese weisen häufig in der Verlaufsuntersuchung eine Größenreduktion auf oder bilden sich spontan zurück. Daher wird für viele subsolide Rundherde primär eine kurzfristige Verlaufskontrolle empfohlen. Da sowohl benigne als auch maligne Veränderungen über einen langen Zeitraum stabil bleiben können, wird in weiterer Folge eine jährliche Kontrolle über einen längeren, derzeit noch unklaren Zeitraum empfohlen. Subsolide Veränderungen, welche an Größe und/oder Dichte zunehmen bzw. einen soliden Anteil innerhalb eines Milchglasrundherdes entwickeln, sind bis zum Beweis des Gegenteils als malignomsuspekt zu werten und müssen weiter abgeklärt werden.
Abstract
The finding of subsolid pulmonary nodules poses a frequent problem in the daily routine of the radiologist. The biological behavior of such subsolid lesions differs significantly from solid nodules. The risk of malignancy is significantly higher in subsolid nodules as compared to solid or purely ground glass opacities or nodules. The recommendations regarding the diagnostic management of subsolid nodules have been adapted according to the tendency of growth and the risk of malignancy. A benign etiology is also seen quite often in subsolid lesions and in this case they will show a reduction of size or disappear completely by the follow-up examination. Therefore, in many cases a short-term follow-up examination is primarily recommended. As the findings will often show no changes for a long period of time, further annual follow-up examinations over a longer, not yet specified period of time are recommended. Subsolid lesions that grow in size and/or show an increase in density or develop a solid part within a ground glass lesion should remain as suspected malignancies until proven otherwise.
Literatur
Aoki T, Tomoda Y, Watanabe H et al (2001) Peripheral lung adenocarcinoma: correlation of thin-section CT findings with histologic prognostic factors and survival. Radiology 220:803–809
Auerbach O, Garfinkel L (1991) The changing pattern of lung carcinoma. Cancer 68:1973–1977
Barsky SH, Cameron R, Osann KE et al (1994) Rising incidence of bronchioloalveolar lung carcinoma and its unique clinicopathologic features. Cancer 73:1163–1170
De Hoop B, Gietema H, Van De Vorst S et al (2010) Pulmonary ground-glass nodules: increase in mass as an early indicator of growth. Radiology 255:199–206
Funama Y, Awai K, Liu D et al (2009) Detection of nodules showing ground-glass opacity in the lungs at low-dose multidetector computed tomography: phantom and clinical study. J Comput Assist Tomogr 33:49–53
Godoy MC, Naidich DP (2012) Overview and strategic management of subsolid pulmonary nodules. J Thorac Imaging 27:240–248
Godoy MC, Naidich DP (2009) Subsolid pulmonary nodules and the spectrum of peripheral adenocarcinomas of the lung: recommended interim guidelines for assessment and management. Radiology 253:606–622
Gould MK, Donington J, Lynch WR et al (2013) Evaluation of individuals with pulmonary nodules: when is it lung cancer? Diagnosis and management of lung cancer, 3rd edn American College of Chest Physicians evidence-based clinical practice guidelines. Chest 143:e93S–e120S
Hansell DM, Bankier AA, Macmahon H et al (2008) Fleischner Society: glossary of terms for thoracic imaging. Radiology 246:697–722
Henschke CI, Yankelevitz DF, Mirtcheva R et al (2002) CT screening for lung cancer: frequency and significance of part-solid and nonsolid nodules. AJR Am J Roentgenol 178:1053–1057
Kim HY, Shim YM, Lee KS et al (2007) Persistent pulmonary nodular ground-glass opacity at thin-section CT: histopathologic comparisons. Radiology 245:267–275
Kim TJ, Park CM, Goo JM et al (2012) Is there a role for FDG PET in the management of lung cancer manifesting predominantly as ground-glass opacity? AJR Am J Roentgenol 198:83–88
Lee SM, Park CM, Goo JM et al (2010) Transient part-solid nodules detected at screening thin-section CT for lung cancer: comparison with persistent part-solid nodules. Radiology 255:242–251
Lee SM, Park CM, Goo JM et al (2013) Invasive pulmonary adenocarcinomas versus preinvasive lesions appearing as ground-glass nodules: differentiation by using CT features. Radiology 268:265–273
Naidich DP, Bankier AA, Macmahon H et al (2013) Recommendations for the management of subsolid pulmonary nodules detected at CT: a statement from the Fleischner Society. Radiology 266:304–317
Oh JY, Kwon SY, Yoon HI et al (2007) Clinical significance of a solitary ground-glass opacity (GGO) lesion of the lung detected by chest CT. Lung Cancer 55:67–73
Ohde Y, Nagai K, Yoshida J et al (2003) The proportion of consolidation to ground-glass opacity on high resolution CT is a good predictor for distinguishing the population of non-invasive peripheral adenocarcinoma. Lung Cancer 42:303–310
Park CM, Goo JM, Kim TJ et al (2008) Pulmonary nodular ground-glass opacities in patients with extrapulmonary cancers: what is their clinical significance and how can we determine whether they are malignant or benign lesions? Chest 133:1402–1409
Park CM, Goo JM, Lee HJ et al (2007) Nodular ground-glass opacity at thin-section CT: histologic correlation and evaluation of change at follow-up. Radiographics 27:391–408
Reich JM (2008) A critical appraisal of overdiagnosis: estimates of its magnitude and implications for lung cancer screening. Thorax 63:377–383
Shimizu K, Ikeda N, Tsuboi M et al (2006) Percutaneous CT-guided fine needle aspiration for lung cancer smaller than 2 cm and revealed by ground-glass opacity at CT. Lung Cancer 51:173–179
Swensen SJ, Jett JR, Hartman TE et al (2005) CT screening for lung cancer: five-year prospective experience. Radiology 235:259–265
Takashima S, Maruyama Y, Hasegawa M et al (2003) CT findings and progression of small peripheral lung neoplasms having a replacement growth pattern. AJR Am J Roentgenol 180:817–826
Travis WD, Brambilla E, Noguchi M et al (2011) International association for the study of lung cancer/american thoracic society/european respiratory society international multidisciplinary classification of lung adenocarcinoma. J Thorac Oncol 6:244–285
Vazquez M, Carter D, Brambilla E et al (2009) Solitary and multiple resected adenocarcinomas after CT screening for lung cancer: histopathologic features and their prognostic implications. Lung Cancer 64:148–154
Welch HG, Black WC (2010) Overdiagnosis in cancer. J Natl Cancer Inst 102:605–613
Yankelevitz DF, Kostis WJ, Henschke CI et al (2003) Overdiagnosis in chest radiographic screening for lung carcinoma: frequency. Cancer 97:1271–1275
Yoshida J, Nagai K, Yokose T et al (2005) Limited resection trial for pulmonary ground-glass opacity nodules: fifty-case experience. J Thorac Cardiovasc Surg 129:991–996
Zhang L, Yankelevitz DF, Carter D et al (2012) Internal growth of nonsolid lung nodules: radiologic-pathologic correlation. Radiology 263:279–286
Einhaltung ethischer Richtlinien
Interessenkonflikt. E. Eisenhuber, G. Mostbeck, H. Prosch, C. Schaefer-Prokop geben an, dass kein Interessenkonflikt besteht. Dieser Beitrag beinhaltet keine Studien an Menschen oder Tieren.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Eisenhuber, E., Mostbeck, G., Prosch, H. et al. Management subsolider pulmonaler Rundherde. Radiologe 54, 427–435 (2014). https://doi.org/10.1007/s00117-013-2602-6
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00117-013-2602-6