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CT und MRT bei intrinsischen raumfordernden Läsionen der knöchernen Schädelbasis

CT and MRI of intrinsic space-occupying lesions of the bony skull base

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Zusammenfassung

Unter intrinsischen Läsionen der knöchernen Schädelbasis versteht man Erkrankungen, die von den die Schädelbasis bildenden Knochen ausgehen. In erster Linie handelt es sich um Knochentumoren und tumorähnliche Läsionen. Mit wenigen Ausnahmen (Nasennebenhöhlenosteome, Exostosen des äußeren Gehörgangs) sind sie selten. Dieser Beitrag gibt einen Überblick über das CT- und MRT-Erscheinungsbild der aus Sicht der Autoren unter diesem Aspekt noch am häufigsten anzutreffenden raumfordernden Läsionen. Dazu zählen die fibröse Dysplasie, Chordome, Chondrosarkome, die Langerhans-Zell-Histiozytose und das multiple Myelom. Abgrenzt werden müssen Pseudotumoren. Artdiagnostische Zuordnungsmöglichkeiten durch CT und/oder MRT, Differenzialdiagnosen und Diagnosesicherung werden dargelegt.

Abstract

Intrinsic bony lesions of the skull base are diseases which arise within the bones forming the skull base. Mainly they are bone tumours and tumour-like lesions. With the exception of osteomas of the paranasal sinuses and exostoses of the external auditory canal, these lesions occur rarely. This article gives an overview of the appearance of the most common primary bony skull base masses in CT and MRI. From the authors’ point of view these are fibrous dysplasia, chordomas, chondrosarcomas, Langerhans cell histiocytosis and multiple myelomas, which must be differentiated from pseudolesions. The possibilities of CT and MRI in making a specific diagnosis, differential diagnosis and the kind of making the final diagnosis are described.

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Literatur

  1. Fletcher CDM, Unni KK, Mertens F (eds) (2002) Word health organisation classification of tumours. Pathology and genetics of tumours of soft tissue and bone. IARC Press, Lyon

  2. Almefty K, Pravdenkova S, Colli BO et al (2007) Chordoma and chondrosarcoma: similar, but quite different, skull base tumors. Cancer 110:2457–2467

    Article  PubMed  Google Scholar 

  3. Rosenberg AE, Nielsen GP, Keel SB et al (1999) Chondrosarcoma of the base of the skull: a clinicopathologic study of 200 cases with emphasis on its distinction from chordoma. Am J Surg Pathol 21:1370–1378

    Article  Google Scholar 

  4. Freyschmidt J, Ostertag H, Jundt G (o J) Knochentumoren. http://www.springer.com/medicine/radiology/bokk/978-3-540-75152-6

  5. Namdar I, Edelstein DR, Huo J et al (1998) Management of osteomas of the paranasal sinuses. Am J Rhinol 12:393–398

    Article  PubMed  CAS  Google Scholar 

  6. Koivunen P, Löppönen H, Fors AP et al (1997) The growth rate of osteomas of paranasal sinuses. Clin Otolaryngol Allied Sci 22:111–114

    Article  PubMed  CAS  Google Scholar 

  7. Kösling S, Kunkel P, Schulz T (2005) Vascular anomalies, sutures and small canals of the temporal bone on axial CT. Eur J Radiol 54:335–343

    Article  Google Scholar 

  8. Madeline LA, Elster AD (1995) Postnatal development of the central skull base: normal variants. Radiology 196:757–763

    PubMed  CAS  Google Scholar 

  9. Rezek PR, Millard M (1963) Autopsy pathology. Thomas, Springfield

  10. Chong VFH, Khoo JBK, Fan Y-F (2002) Fibrous dysplasia involving the base of the skull. Am J Radiol 178:717–720

    Google Scholar 

  11. Sharma RR, Mahapatra AK, Pawer SJ et al (2002) Symptomatic cranial fibrous dysplasias: clinico-radiological analysis in a series of eight operative cases with follow-up results. J Clin Neurosci 9:381–390

    Article  PubMed  Google Scholar 

  12. Kösling S, Knipping S, Stoevesandt D (2007) Tumoren und tumorähnliche Erkrankungen. Radiologe 47:613–620

    Article  PubMed  Google Scholar 

  13. Commins DJ, Tolley NS, Milford CA (1998) Fibrous dysplasia and ossifying fibroma of the paranasal sinuses. J Laryngol Otol 112:964–968

    Article  PubMed  CAS  Google Scholar 

  14. Kuttenberger JJ, Hardt N, Gebbers JO (2003) Juveniles ossifizierendes Fibrom. Mund Kiefer Gesichtschir 7:47–51

    PubMed  CAS  Google Scholar 

  15. Pieper DR, Ossama A, Hanada Y et al (1999) Hyperostosis associated with meningioma of the cranial base: secondary changes or tumor invasion. Neurosurgery 44:742–747

    Article  PubMed  CAS  Google Scholar 

  16. Devi B, Madhusudhan DBHV, Santhosh V et al (2001) Primary intraosseous meningioma of orbit and anterior cranial fossa. Aust Radiol 45:211–214

    Article  CAS  Google Scholar 

  17. Morita A, Sekhar LN, Wright DC (1998) Current concepts in the management of tumors of the skull base. Cancer Control 5:138–149

    PubMed  Google Scholar 

  18. Gavril C, Bouvier C, Liprandi A et al (2002) Pathology of myxoid bone tumors of the skull base. Ann Pathol 22:259–266

    PubMed  Google Scholar 

  19. Rossiello R, Ferrara G, Varricchio A et al (2001) Chondroid chordoma of the lateral skull base. ORL 63:114–118

    Article  PubMed  CAS  Google Scholar 

  20. Tsuboi Y, Hayashi N, Kurimoto M et al (2007) Malignent transformation of clival chordoma after gamma knife surgery. Neurol Med Chir 47:479–482

    Article  Google Scholar 

  21. Yamaguchi T, Watanabe-Ischiiwa H, Suzuki S et al (2005) Incipient chordoma: a report of early-stage chordomas arising from benign notochordal tumors. Mod Pathol 18:1005–1010

    Article  PubMed  Google Scholar 

  22. Oikawa S, Kyoshima K, Goto T et al (2001) Histological study on local invasiveness of clival chordoma. Acta Neurochir 143:1065–1069

    Article  CAS  Google Scholar 

  23. Gupta A, Harnsberger HR (2004) Chordoma, clivus. In: Harnsberger HR (ed) Diagnostic imaging. Head Neck. Armirsys, Salt Lake City, I-3–I-10

  24. Keel SB, Bhan AK, Liebsch NJ et al (1997) Chondromyxoid fibroma of the skull base: a tumor which may be confused with chordoma and chondrosarcoma. A report of three cases and review of literature. Am J Surg Pathol 21:577–582 3

    Article  PubMed  CAS  Google Scholar 

  25. Moorthy RK, Daniel RT, Rajshekhar V et al (2002) Skull base chondroblastoma: a case report. Neurol India 50:534–536

    PubMed  CAS  Google Scholar 

  26. Kösling S, Hintner M, Brandt S et al (2004) Mucoceles of the sphenoid sinus. Eur J Radiol 51:1–5

    Article  PubMed  Google Scholar 

  27. Korten AGGC, terBerg HJW, Spincemaille GH et al (1998) Intracranial chondrosarcoma: review of the literature and report of 15 cases. J Neurol Neurosurg Psych 65:88–92

    Article  CAS  Google Scholar 

  28. Seizure R, Forlodou P, Quintin-Roue I et al (2008) Chondrosarcoma of the skull base in Maffucci’s syndrome. Br J Neurosurg 22:778–780

    Article  Google Scholar 

  29. Schaumann C, Kösling S, Meister EF et al (1995) Computertomographisches Erscheinungsbild von Chondrosarkomen im Kopf-Hals-Bereich. Fortschr Röntgenstr 163:274–276

    Article  CAS  Google Scholar 

  30. Harada K, Nakahara I, Hayashi J et al (2006) Chondrosarcoma of the clivus presenting with intratumoral hemorrhage: case report. J Neuro-Oncol 77:221–223

    Google Scholar 

  31. Neff B, Sataloff T, Storey L et al (2002) Chondrosarcoma of the skull base. Laryngoscope 112:134–139

    Article  PubMed  Google Scholar 

  32. AWMF online. Leitlinie Langerhanszell-Histiozytose. http://www.uni-duesseldorf.de/AWMF

  33. Hudgins PA (2004) Langerhans histiocytosis. In: Harnsberger HR (ed) Diagnostic imaging. Head Neck. Armirsys, Salt Lake City, I-3–I-62

  34. AWMF online. Leitlinie Multiples Myelom. http://www.uni-duesseldorf.de/AWMF

  35. Schwartz TH, Rhiew R, Isaacson SR et al (2001) Association between intracranial plasmacytoma and multiple myeloma: clinicopathological outcome study. Neurosurg 49:1039–1044

    Article  CAS  Google Scholar 

  36. Vijaya-Sekaran S, Delap T, Abramovich S (1999) Solitary plasmacytoma of the skull base presenting with unilateral sensorineural hearing loss. J Laryngol Otol 113:164–166

    Article  PubMed  CAS  Google Scholar 

  37. Tsai VW, Rybak L, Espoinosa J et al (2002) Primary B-cell lymphoma of the clivus. Surg Neurol 58:246–250

    Article  PubMed  Google Scholar 

  38. Choi HK, Cheon JE, Kim IO et al (2008) Central skull base lymphoma in children: MR and CT features. Pediatr Radiol 38:864–867

    Google Scholar 

  39. Manucusi G, Marks B, Czerny C et al (2005) Tuberkulöse Osteomyelitis des Klivus mit Beteiligung des Nasopharynx. HNO 53:1081–1084

    Article  Google Scholar 

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Danksagung

Wir bedanken uns bei den Mitarbeitern der Institute für Pathologie der Universitäten Halle bzw. Leipzig für die Zurverfügungstellung der histologischen Diagnosen.

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Die korrespondierende Autorin gibt an, dass kein Interessenkonflikt besteht.

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Kösling, S., Neumann, K. & Brandt, S. CT und MRT bei intrinsischen raumfordernden Läsionen der knöchernen Schädelbasis. Radiologe 49, 598–607 (2009). https://doi.org/10.1007/s00117-008-1802-y

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