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Der Nervenarzt

, Volume 89, Issue 4, pp 443–445 | Cite as

Bei Morbus Parkinson und progredienter Dysphagie an Myasthenia gravis denken

  • P. P. Urban
  • O. Stammel
Originalien

Zusammenfassung

Wir berichten über vier konsekutive Patienten mit M. Parkinson, bei denen sich als ursächlich für die progrediente Dysphagie eine antikörperpositive bulbäre Myasthenia gravis (MG) ohne Generalisierungstendenz herausstellte.

Schlüsselwörter

M. Parkinson Myasthenia gravis Dysphagie Dysarthrie Acetylcholinrezeptorantikörper 

Myasthenia gravis should be considered in cases of Parkinson’s disease and progressive dysphagia

Abstract

We report on four consecutive patients with Parkinson’s disease, in whom anti-acetylcholine receptor (AChR) antibody positive bulbar myasthenia gravis (MG) turned out to be responsible for progressive dysphagia.

Keywords

Parkinson’s disease Myasthenia gravis Dysphagia Dysarthria Acetylcholine receptor antibody 

Notes

Einhaltung ethischer Richtlinien

Interessenkonflikt

P.P. Urban und O. Stammel geben an, dass kein Interessenkonflikt besteht.

Dieser Beitrag beinhaltet keine von den Autoren durchgeführten Studien an Menschen oder Tieren. Alle Patienten, die über Bildmaterial oder anderweitige Angaben innerhalb des Manuskripts zu identifizieren sind, haben hierzu ihre schriftliche Einwilligung gegeben.

Literatur

  1. 1.
    Aiba Y, Iwakawa M, Sakakibara R et al (2016) Myasthenia gravis manifesting as head drop in an elderly adult with Parkinson’s disease. J Am Geriatr Soc 64:e120–e122CrossRefPubMedGoogle Scholar
  2. 2.
    Fasano A, Evoli A, Piaono C, Tonali PA, Bentivoglio AR (2008) Myasthenia gravis: an unrecognized cause of head drop in Parkinson’s disease. Parkinsonism Relat Disord 14:164–165CrossRefPubMedGoogle Scholar
  3. 3.
    Hwang WJ, Lin TS (2001) Evaluation of fatigue in Parkinson’s disease patients with stimulated single fibre electromyography. Acta Neurol Scand 104:271–274CrossRefPubMedGoogle Scholar
  4. 4.
    Iwasaki Y, Wakata N, Kinoshita M (1988) Parkinsonism induced by pyridostigmine. Acta Neurol Scand 78:236CrossRefPubMedGoogle Scholar
  5. 5.
    Kao KP, Kwan SY, Lin KP, Chang YC (1993) Coexistence of Parkinson’s disease and myasthenia gravis: a case report. Clin Neurol Neurosurg 95:137–139CrossRefPubMedGoogle Scholar
  6. 6.
    Levin N, Karussis D, Abramsky O (2003) Parkinson’s disease associated with myasthenia gravis. J Neurol 250:766–767CrossRefPubMedGoogle Scholar
  7. 7.
    Llabrés M, Molina-Martinez FJ, Miralles F (2006) Dysphagia as the sole manifestation of myasthenia gravis. J Neurol Neurosurg Psychiatr 76:1297–1300CrossRefGoogle Scholar
  8. 8.
    Sciacca G, Nicoletti A, Mostile G et al (2016) Is it just a coincidence? Three new cases of myasthenia gravis associated with Parkinson’s disease. Parkinsonism Relat Disord 28:166–168CrossRefPubMedGoogle Scholar
  9. 9.
    Somnier FE (2005) Increasing incidence of late-onset anti-AChR antibody-seropositive myasthenia gravis. Neurology 65:928–930CrossRefPubMedGoogle Scholar
  10. 10.
    Suttrup I, Warnecke T (2016) Dysphagia in Parkinson’s disease. Dysphagia 31:24–32CrossRefPubMedGoogle Scholar
  11. 11.
    Tung-Chen Y et al (2016) Co-occurrence of myasthenia gravis with Parkinson’s disease: a not to be missed diagnosis. Geriatr Gerontol Int 16:528–530CrossRefPubMedGoogle Scholar
  12. 12.
    Ueno S, Takahashi M, Kajiyama K et al (1987) Parkinson’s disease and myasthenia gravis: adverse effect of trihexphenidyl on neuromuscular transmission. Neurology 37:832–833CrossRefPubMedGoogle Scholar
  13. 13.
    Uludag IF, Korucuk M, Sener U, Zorlu Y (2011) Myasthenia gravis as a cause of head drop in Parkinson Disease. Neurologist 17:144–146CrossRefPubMedGoogle Scholar
  14. 14.
    Unal-Cevik I, Temucin CM (2009) Head drop in an elder Parkinson’s disease after development of myasthenia gravis. Mov Disord 24:2025–2026CrossRefPubMedGoogle Scholar
  15. 15.
    Warnecke T, Dziewas (2013) Neurogene dysphagien. Kohlhammer, Stuttgart, S 50–53Google Scholar
  16. 16.
    Zis P, Argiriadou V, Temperikidis P et al (2014) Parkinson’s disease associated with myasthenia gravis and rheumatoid arthritis. Neurol Sci 35:797–799CrossRefPubMedGoogle Scholar

Copyright information

© Springer Medizin Verlag GmbH 2017

Authors and Affiliations

  1. 1.Abt. für NeurologieAsklepios Klinik BarmbekHamburgDeutschland

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