Fig. 4 | Journal of Molecular Medicine

Fig. 4

From: Glucocorticoids dexamethasone and prednisolone suppress fibroblast growth factor 23 (FGF23)

Fig. 4

Impact of dexamethasone on 1,25(OH)2D3 formation, metabolism and PTH serum level. Arithmetic means ± SEM (n = 6) of the 1,25(OH)2D3 (a) and intact PTH (b) serum concentration in control mice (ctr, white bars) and mice treated with 20 mg/kg body weight dexamethasone (DEXA, black bars) 12 h after the injection. Arithmetic means ± SEM (n = 6, arbitrary units (a. u.)) of relative mRNA transcript levels of Cyp27b1 (c) and Cyp24a1 (d) normalized to Gapdh in kidneys from mice 12 h after the injection of vehicle only (ctr, white bars) or 20 mg/kg body weight dexamethasone (DEXA, black bars). **p < 0.01, ***p < 0.001 indicate statistically significant differences from control-treated mice. (a, b and d: unpaired t test; c: unpaired t test with Welch’s correction)

Back to article page