Die 8. Version der TNM-Klassifikation – Fluch oder Segen für das Oropharynxkarzinom?

The 8th edition of the TNM staging system—a curse or a blessing for oropharyngeal carcinoma?

Zusammenfassung

Zu Beginn des Jahres 2017 wurde die 8. Version der TNM-Klassifikation vorgestellt. Für das Oropharynxkarzinom bedeutete dies einen Paradigmenwechsel, da eine Trennung der Klassifikation in Abhängigkeit zur Assoziation mit einer Humanen-Papillomvirus-Koinfektion (HPV) hergestellt wurde. Unter Berücksichtigung der Literatur soll hier eine Übersicht über die Besonderheiten HPV-assoziierter Karzinome, die Neuerungen der TNM-Klassifikationen sowie die bestehenden Diskussionspunkte gegeben werden. Durch die Revision wurde die prognostische Aussagekraft der TNM-Klassifikation verbessert. Es bestehen jedoch weiterhin tumor- und patientenabhängige Einflussfaktoren, die bei der Erstellung von zukünftigen Versionen berücksichtigt werden müssen.

Abstract

At the beginning of 2017, the 8th edition of the TNM classification was presented. For oropharyngeal carcinoma, this was accompanied by a paradigm shift, as a separation of the classification depending on the association with human papillomavirus (HPV) status has been established. By considering the literature, this paper provides an overview of the characteristics of HPV-associated carcinomas, the new features of the TNM classification, and the existing points of discussion. The revision has improved the prognostic significance of the TNM classification; however, there are still tumor- and patient-dependent influencing factors that must be considered for future versions.

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Correspondence to Dr. C. Becker.

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Interessenkonflikt

C. Becker, B.G. Hofauer, N. Mansour, M.C. Ketterer, T. Schulz und A. Knopf geben an, dass kein Interessenkonflikt besteht.

Für diesen Beitrag wurden von den Autoren keine Studien an Menschen oder Tieren durchgeführt. Für die aufgeführten Studien gelten die jeweils dort angegebenen ethischen Richtlinien.

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Becker, C., Hofauer, B.G., Mansour, N. et al. Die 8. Version der TNM-Klassifikation – Fluch oder Segen für das Oropharynxkarzinom?. HNO 69, 89–94 (2021). https://doi.org/10.1007/s00106-020-00875-4

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Schlüsselwörter

  • UICC
  • Humanes Papillomvirus
  • p16
  • Prognose
  • Kopf-Hals-Karzinom

Keywords

  • UICC
  • Human papillomavirus
  • p16
  • Prognosis
  • Head-neck-cancer