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Neue Perspektiven des Skelettmuskel-Tissue-Engineerings

New perspectives in skeletal muscle tissue engineering

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Zusammenfassung

Die Entwicklungen im Bereich des Skelettmuskel-Tissue-Engineerings sind durch den enormen Wissenszuwachs im Bereich der Stammzellforschung und der Biomaterialien rasant. In diesem Artikel wird ein allgemeiner Überblick über das Forschungsgebiet des Skelettmuskel-Tissue-Engineerings gegeben, aktuelle Erkenntnisse werden diskutiert und einige neue Perspektiven aufgezeigt. Des Weiteren werden Ergebnisse zur myogenen Differenzierung von humanen mesenchymalen Stammzellen und Satellitenzellen präsentiert.

Abstract

Due to the enormous expansion of knowledge in the fields of stem cell research and biomaterials, skeletal muscle tissue engineering represents a rapidly developing field of biomedical research. This article provides a general overview of skeletal muscle tissue engineering, including a discussion of recent findings and future research perspectives. Additionally, the results of myogenic differentiation of human mesenchymal stem cells and satellite cells are presented.

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Einhaltung ethischer Richtlinien

Interessenkonflikt. J. Stern-Straeter und K. Hörmann geben an, dass kein Interessenkonflikt besteht. Diese Arbeit enthält Teilaspekte der Habilitationsschrift des Erstautors J. Stern-Straeter.

Alle im vorliegenden Manuskript beschriebenen Untersuchungen am Menschen wurden mit Zustimmung der zuständigen Ethik-Kommission, im Einklang mit nationalem Recht sowie gemäß der Deklaration von Helsinki von 1975 (in der aktuellen, überarbeiteten Fassung) durchgeführt. Von allen beteiligten Patienten liegt eine Einverständniserklärung vor.

Alle nationalen Richtlinien zur Haltung und zum Umgang mit Labortieren wurden eingehalten und die notwendigen Zustimmungen der zuständigen Behörden liegen vor.

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Authors and Affiliations

  1. Universitäts-Hals-Nasen-Ohren-Klinik Mannheim, Medizinische Fakultät Mannheim der Universität Heidelberg, Theodor-Kutzer-Ufer-1–3, 68167, Mannheim, Deutschland

    J. Stern-Straeter & K. Hörmann

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  1. J. Stern-Straeter
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  2. K. Hörmann
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Correspondence to J. Stern-Straeter.

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Stern-Straeter, J., Hörmann, K. Neue Perspektiven des Skelettmuskel-Tissue-Engineerings. HNO 62, 415–422 (2014). https://doi.org/10.1007/s00106-014-2863-z

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  • DOI: https://doi.org/10.1007/s00106-014-2863-z

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