Zusammenfassung
Extremitätensarkome sind seltene bösartige Tumoren. Die Behandlung erfordert ein erfahrenes Team. Die Primärdiagnostik mit adäquater lokaler Bildgebung und Biopsie hat einen sehr hohen Stellenwert. Vor der Operation sollten die multimodale Behandlung und das Ausmaß der Resektion und ggf. Rekonstruktion interdisziplinär festgelegt werden. Ziel der Resektion ist immer die vollständige R0-Resektion unter optimalem Funktionserhalt. Im multimodalen Therapiesetting kann im erfahrenen Team ein Erhalt funktionskritischer Strukturen (z. B. Nervus ischiadicus) durch eine fokal-marginale Resektion erreicht werden.
Abstract
Soft tissue sarcomas of the extremities are rarely malignant tumors. They are best treated by an experienced interdisciplinary sarcoma team. A preoperative biopsy and imaging are prerequisites for successful sarcoma treatment. Before surgery the multimodal treatment and the extent of resection and, if necessary, plastic reconstruction should be discussed in a multidisciplinary tumor board. The aim is always a complete R0 resection with optimal preservation of function. The preservation of critical structures (e. g. sciatic nerve) by a planned focal marginal resection along the critical structure can be performed by an experienced team in a multidisciplinary treatment setting.
Literatur
Berger-Richardson D, Swallow CJ (2017) Needle tract seeding after percutaneous biopsy of sarcoma: risk/benefit considerations. Cancer 123:560–567
Blay JY, Soibinet P, Penel N et al (2017) Improved survival using specialized multidisciplinary board in sarcoma patients. Ann Oncol 28:2852–2859
Callegaro D, Miceli R, Bonvalot S et al (2016) Development and external validation of two nomograms to predict overall survival and occurrence of distant metastases in adults after surgical resection of localised soft-tissue sarcomas of the extremities: a retrospective analysis. Lancet Oncol 17:671–680
Casali PG, Abecassis N, Bauer S et al (2018) Soft tissue and visceral sarcomas: ESMO-EURACAN clinical practice guidelines for diagnosis, treatment and follow-up. Ann Oncol 29:iv51–iv67
Chhabra A, Ashikyan O, Slepicka C et al (2018) Conventional MR and diffusion-weighted imaging of musculoskeletal soft tissue malignancy: correlation with histologic grading. Eur Radiol. https://doi.org/10.1007/s00330-018-5845-9
Davis AM, O’sullivan B, Bell RS et al (2002) Function and health status outcomes in a randomized trial comparing preoperative and postoperative radiotherapy in extremity soft tissue sarcoma. J Clin Oncol 20:4472–4477
De La Hoz Polo M, Dick E, Bhumbra R et al (2017) Surgical considerations when reporting MRI studies of soft tissue sarcoma of the limbs. Skeletal Radiol 46:1667–1678
Erstad DJ, Ready J, Abraham J et al (2018) Amputation for extremity sarcoma: contemporary indications and outcomes. Ann Surg Oncol 25:394–403
Fischer S, Soimaru S, Hirsch T et al (2015) Local tendon transfer for knee extensor mechanism reconstruction after soft tissue sarcoma resection. J Plast Reconstr Aesthet Surg 68:729–735
Furtado S, Grimer RJ, Cool P et al (2015) Physical functioning, pain and quality of life after amputation for musculoskeletal tumours: a national survey. Bone Joint J 97-b:1284–1290
Gronchi A, Ferrari S, Quagliuolo V et al (2017) Histotype-tailored neoadjuvant chemotherapy versus standard chemotherapy in patients with high-risk soft-tissue sarcomas (ISG-STS 1001): an international, open-label, randomised, controlled, phase 3, multicentre trial. Lancet Oncol 18:812–822
Gundle KR, Kafchinski L, Gupta S et al (2018) Analysis of margin classification systems for assessing the risk of local recurrence after soft tissue sarcoma resection. J Clin Oncol 36:704–709
Haas RL, Delaney TF, O’sullivan B et al (2012) Radiotherapy for management of extremity soft tissue sarcomas: why, when, and where? Int J Radiat Oncol Biol Phys 84:572–580
Harati K, Goertz O, Pieper A et al (2017) Soft tissue sarcomas of the extremities: surgical margins can be close as long as the resected tumor has no ink on it. Oncologist 22:1400–1410
Jakob J, Hohenberger P (2016) Role of isolated limb perfusion with recombinant human tumor necrosis factor alpha and melphalan in locally advanced extremity soft tissue sarcoma. Cancer 122:2624–2632
Kainhofer V, Smolle MA, Szkandera J et al (2016) The width of resection margins influences local recurrence in soft tissue sarcoma patients. Eur J Surg Oncol 42:899–906
Lansu J, Groenewegen J, Van Coevorden F et al (2018) Time dependent dynamics of wound complications after preoperative radiotherapy in extremity soft tissue sarcomas. Eur J Surg Oncol. https://doi.org/10.1016/j.ejso.2018.09.001
O’sullivan B, Davis AM, Turcotte R et al (2002) Preoperative versus postoperative radiotherapy in soft-tissue sarcoma of the limbs: a randomised trial. Lancet 359:2235–2241
Pasquali S, Colombo C, Pizzamiglio S et al (2018) High-risk soft tissue sarcomas treated with perioperative chemotherapy: improving prognostic classification in a randomised clinical trial. Eur J Cancer 93:28–36
Perrier L, Buja A, Mastrangelo G et al (2012) Clinicians’ adherence versus non adherence to practice guidelines in the management of patients with sarcoma: a cost-effectiveness assessment in two European regions. BMC Health Serv Res 12:82
Pohlig F, Kirchhoff C, Lenze U et al (2012) Percutaneous core needle biopsy versus open biopsy in diagnostics of bone and soft tissue sarcoma: a retrospective study. Eur J Med Res 17:29
Qureshi YA, Huddy JR, Miller JD et al (2012) Unplanned excision of soft tissue sarcoma results in increased rates of local recurrence despite full further oncological treatment. Ann Surg Oncol 19:871–877
Ressing M, Wardelmann E, Hohenberger P et al (2018) Strengthening health data on a rare and heterogeneous disease: sarcoma incidence and histological subtypes in Germany. BMC Public Health 18:235
Smith HG, Thomas JM, Smith MJF et al (2018) Major amputations for extremity soft-tissue sarcoma. Ann Surg Oncol 25:387–393
Smolle MA, Leithner A, Grimer RJ (2015) Evaluating the British sarcoma referral form. Ann R Coll Surg Engl 97:434–438
Smolle MA, Tunn PU, Goldenitsch E et al (2017) The prognostic impact of unplanned excisions in a cohort of 728 soft tissue sarcoma patients: a multicentre study. Ann Surg Oncol 24:1596–1605
Townley WA, Mah E, O’Neill AC et al (2013) Reconstruction of sarcoma defects following pre-operative radiation: free tissue transfer is safe and reliable. J Plast Reconstr Aesthet Surg 66:1575–1579
Traub F, Griffin AM, Wunder JS et al (2018) Influence of unplanned excisions on the outcomes of patients with stage III extremity soft-tissue sarcoma. Cancer 124:3868–3875
Von Mehren M, Randall RL, Benjamin RS et al (2018) Soft tissue sarcoma, version 2.2018, NCCN clinical practice guidelines in oncology. J Natl Compr Canc Netw 16:536–563
Woll PJ, Reichardt P, Le Cesne A et al (2012) Adjuvant chemotherapy with doxorubicin, ifosfamide, and lenograstim for resected soft-tissue sarcoma (EORTC 62931): a multicentre randomised controlled trial. Lancet Oncol 13:1045–1054
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Interessenkonflikt
J. Jakob erhielt Vortragshonorare der Firma Lilly Deutschland. J. Schmolders gibt an, dass kein Interessenkonflikt besteht.
Dieser Beitrag beinhaltet keine von den Autoren durchgeführten Studien an Menschen oder Tieren.
Rights and permissions
About this article
Cite this article
Jakob, J., Schmolders, J. Systematik in der Operationsplanung bei Weichgewebesarkomen der Extremitäten. Chirurg 90, 441–446 (2019). https://doi.org/10.1007/s00104-019-0921-5
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00104-019-0921-5