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Resektionskonzepte bei frühen neuroendokrinen Tumoren der Lunge und Bronchien

Resection concepts for early stage neuroendocrine tumors of the lungs and bronchi

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Zusammenfassung

Hintergrund

Neuroendokrine Tumoren der Lunge sind eine heterogene Erkrankungsgruppe und bedürfen im Frühstadium einer daran angepassten chirurgischen Therapie.

Ziel der Arbeit

Der Leser soll die Indikationen für die verschiedenen chirurgischen Therapieformen in Abhängigkeit der genauen Lokalisation und Histologie der thorakalen neuroendokrinen Tumoren kennenlernen und ein Verständnis für das präoperative Staging, die funktionelle Abklärung sowie das perioperative Management dieser Patienten entwickeln.

Material und Methoden

Wir führten eine selektive Literaturrecherche durch und ergänzten diesen Artikel mit eigenen Erfahrungen.

Schlussfolgerung

Die sehr inhomogene Gruppe von Lungentumoren, welche der neuroendrokinen Differenzierungslinie entstammt, bedarf im Frühstadium einer individualisierten chirurgischen Therapie. Eine radikale R0-Resektion trägt über alle histologischen Gruppen zu einer verbesserten Langezeitprognose bei.

Abstract

Background

Neuroendocrine tumors of the lungs are a very inhomogeneous group of malignancies. The surgical treatment should be adapted to the anatomical localization and histological subtype and individualized according to the functional reserve.

Material and methods

We performed a selective review of current literature, which was supplemented by personal experiences.

Results

The currently available outcome data are very inhomogeneous and depend on the histological subtype of neuroendocrine pulmonary tumors. A radical R0 resection is the key for an improvement in long-term overall and disease-free survival.

Conclusion

Surgical treatment of carcinoid tumors is the current standard therapy. Sleeve resection should be performed, whenever possible. More aggressive tumors, such as large cell neuroendocrine carcinoma and small cell lung cancer should be treated in a multimodal concept.

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Authors and Affiliations

  1. Abteilung für Thoraxchirurgie und thorakale Endoskopie, Universitätsmedizin Essen – Ruhrlandklinik, Tüschener Weg 40, 45239, Essen, Deutschland

    T. Ploenes &  C. Aigner

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  1. T. Ploenes
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  2. C. Aigner
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Correspondence to C. Aigner.

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T. Ploenes und C. Aigner geben an, dass kein Interessenkonflikt besteht.

Dieser Beitrag beinhaltet keine von den Autoren durchgeführten Studien an Menschen oder Tieren.

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Ploenes, T., Aigner, C. Resektionskonzepte bei frühen neuroendokrinen Tumoren der Lunge und Bronchien. Chirurg 89, 440–447 (2018). https://doi.org/10.1007/s00104-017-0558-1

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