Zusammenfassung
Gegenstand dieser Übersichtsarbeit ist die Diagnostik, Therapie, Nachsorge und Prognose intraabdomineller und retroperitonealer Weichgewebssarkome. Beschrieben und diskutiert werden chirurgische Verfahren, die Vor- und Nachteile verschiedener Formen und Kombinationen adjuvanter und neoadjuvanter Therapien, die Therapie bei Irresektabilität und das Vorgehen bei Desmoidtumoren. Behandlungsergebnisse, Überwachungsstrategien und Studien, die sich mit neuen Therapieansätzen beschäftigen, werden vorgestellt.
Abstract
In this article, we review the diagnostics, therapy, follow-up, and prognosis of intra-abdominal and retroperitoneal soft tissue sarcomas. There are descriptions and discussion of the surgical techniques, advantages and disadvantages of various types and combinations of adjuvant and neoadjuvant therapies, therapy in case of nonresectability, and procedures for desmoid tumors. Further, treatment results, control methods, and studies on new therapeutic approaches are presented.
Literatur
Borden EC, Baker LH, Bell RS et al. (2003) Soft tissue sarcomas of adults: state of the translational science. Clin Cancer Res 9:1941–1956
Catton CN, O’Sullivan B, Kotwall et al. (1994) Outcome and prognosis in retroperitoneal soft tissue sarcoma. Int J Radiat Oncol Biol Phys 29:1005–1010
Coindre JM, Mariani O, Chibon F et al. (2003) Most malignant fibrous histiocytomas developed in the retroperitoneum are dedifferentiated liposarcomas: a review of 25 cases initially diagnosed as malignant fibrous histiocytomas. Mod Pathol 16:256–262
vanDoorn RC, Gallee MP, Hart AA et al. (1994) Resectable retroperitoneal soft tissue sarcoma: the effect of extent of resection and postoperative radiation therapy on local tumor control. Cancer 73:637–742
ESMO Guidelines Task Force (2003) Minimum clinical recommendations for diagnosis, treatment, and follow-up for soft tissue sarcomas. August 2003
Glenn J, Sindelar WF, Kinsella T et al. (1985) Results of multimodality therapy of resectable soft tissue sarcomas of the retroperitoneum. Surgery 97:316–324
Heslin MJ, Lewis JJ, Nadler E et al. (1997) Prognostic factors associated with long-term survival for retroperitoneal sarcoma: implications for management. J Clin Oncol 15:2832–2839
Hollenbeck ST, Grobmyer SR, Kent KC et al. (2003) Surgical treatment and outcome of patients with primary inferior vena cava leiomyosarcoma. J Am Coll Surg 197:575–579
Ioannidis JPA, Lau J (2003) 18F-FDG PET for the diagnosis and grading of soft-tissue sarcoma: a meta-analysis. J Nucl Med 44:717–724
Israel-Mardirosian N, Adler LP (2003) Positron emission tomography of soft tissue sarcomas. Curr Opin Oncol 15:327–330
Jaques DP, Coit DG, Hajdu SI, Brennan MF (1990) Management of primary and recurrent soft tissue sarcoma of the retroperitoneum. Ann Surg 212:51–59
Jemal A, Tiwari RC, Murray T et al. (2004) Cancer statistics 2004. CA Cancer J Clin 54:8–29
Kattan MW, Leung DH, Brennan MF (2002) Postoperative nomogram for 12-year sarcoma-specific death. J Clin Oncol 20:791–796
Lewis JJ, Leung DH, Woodruff JM, Brennan MF (1998) Retroperitoneal soft-tissue sarcoma: analysis of 500 patients treated and followed at a single institution. Ann Surg 228:355–365
Ling CC, Humm J, Larson S et al. (2000) Towards multidimensional radiotherapy (MD-CRT): biological imaging and biological conformality. Int J Radiation Oncology Biol Phys 47:551–560
DeMatteo RP, Shah A, Fong Y et al. (2001) Results of hepatic resection for sarcoma metastatic to liver. Ann Surg 234:540–548
Nutting C, Dearnaley DB, Webb S (2000) Intensity modulated radiation therapy: a clinical review. Br J Radiol 73:459–469
Pisters PWT, O’Sullivan B (2002) Retroperitoneal sarcomas: combined modality treatment approaches. Curr Opin Oncol 14:400–405
deSaint Aubain Somerhausen N, Fletcher CD (1999) Soft tissue sarcomas: an update. Eur J Surg Oncol 25:215–220
Shibata D, Lewis JJ, Leung DH, Brennan MF (2001) Is there a role for incomplete resection in the management of retroperitoneal liposarcomas? J Am Coll Surg 193:373–379
Singer S, Antonescu CR, Riedel E, Brennan MF (2003) Histologic subtype and margin of resection predict pattern of recurrence and survival for retroperitoneal liposarcoma. Ann Surg 238:358–371
Smith AJ, Lewis JJ, Merchant NB et al. (2000) Surgical management of intra-abdominal desmoid tumors. Br J Surg 87:608–613
Stojadinovic A, Yeh A, Brennan MF (2002) Completely resected recurrent soft tissue sarcoma: primary anatomic site governs outcomes. J Am Coll Surg 194:436–447
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Der Beitrag wurde übersetzt von Dr. Burkhard H. A. von Rahden, Chirurgische Klinik, Klinikum rechts der Isar, TU München.
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Wong, S., Brennan, M.F. Therapeutisches Management intraabdomineller und retroperitonealer Weichgewebssarkome. Chirurg 75, 1174–1181 (2004). https://doi.org/10.1007/s00104-004-0961-2
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DOI: https://doi.org/10.1007/s00104-004-0961-2