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Intoxikation nach Frostschutzmittelaufnahme

Der Fall eines Patienten nach wiederholter Ethylenglykolintoxikation

Antifreeze poisoning

The case of a patient with repeated ethylene glycol poisoning

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An Erratum to this article was published on 20 April 2021

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Zusammenfassung

Eine akzidentielle oder (para)suizidale Intoxikation mit Ethylenglykol kann zu einer schweren Acidose, zu verschiedenen Organsystemschäden und zum Tod führen. Wirksame Therapien stellen die Hämodialyse und die sofortige Gabe von Fomepizol bzw. von Ethanol dar. Wir beschreiben einen Patienten nach wiederholter Ethylenglykolintoxikation mit einer schweren metabolischen Acidose und einem akuten Nierenversagen. Durch Hämodialyse mit ethanolhaltigem Dialysat und i. v.-Gabe von Ethanol konnten wir gravierende Folgeschäden verhindern.

Abstract

Ethylene glycol poisoning of incidental or suicidal intention can cause life-threatening metabolic acidosis, diverse secondary damage, and even lead to death. Beside hemodialysis effective therapy consists of the administration of fomepizole and ethanol. We describe a patient after repeated ethylene glycol poisoning with high anion gap metabolic acidosis and acute renal failure. Using hemodialysis, with dialysate containing a specific amount of ethanol, and intravenous ethanol administration we were able to prevent severe secondary organ damage.

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Authors and Affiliations

  1. Klinik I für Innere Medizin, Universitätsklinikum Köln, Kerpener Str. 62, 50937, Köln, Deutschland

    J. Prinz, B. Böll, A. Shimabukuro-Vornhagen & M. Kochanek

  2. Medizinische Klinik und Poliklinik III, Klinikum der Universität München, München, Deutschland

    M. von Bergwelt-Baildon

  3. Klinik II für Innere Medizin, Universitätsklinikum Köln, Köln, Deutschland

    V. Burst

  4. Institut für Pathologie, Universitätsklinikum Köln, Köln, Deutschland

    J. U. Becker

  5. Serviço de Nefrologia, Hospital do Espírito Santo, Évora, Portugal

    D. Carvalho-Fiel

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  1. J. Prinz
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  2. B. Böll
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  3. M. von Bergwelt-Baildon
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  4. V. Burst
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  5. J. U. Becker
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  6. D. Carvalho-Fiel
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  7. A. Shimabukuro-Vornhagen
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  8. M. Kochanek
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Corresponding author

Correspondence to J. Prinz.

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Interessenkonflikt

J. Prinz, B. Böll, M. von Bergwelt-Baildon, V. Burst, J. U. Becker, D. Carvalho-Fiel, A. Shimabukuro-Vornhagen und M. Kochanek geben an, dass kein Interessenkonflikt besteht.

Dieser Beitrag beinhaltet keine von den Autoren durchgeführten Studien an Menschen oder Tieren. Alle Patienten, die über Bildmaterial oder anderweitige Angaben innerhalb des Manuskripts zu identifizieren sind, haben hierzu ihre schriftliche Einwilligung gegeben.

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R. Riessen, Tübingen

Die ursprüngliche Online-Version dieses Artikels wurde überarbeitet: Der Name des Autors M. von Bergwelt-Baildon wurde korrigiert.

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Prinz, J., Böll, B., von Bergwelt-Baildon, M. et al. Intoxikation nach Frostschutzmittelaufnahme. Med Klin Intensivmed Notfmed 114, 159–163 (2019). https://doi.org/10.1007/s00063-018-0439-5

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  • DOI: https://doi.org/10.1007/s00063-018-0439-5

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