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Molekulare Mechanismen von Vorhofflimmern

Potenzielle Rolle der microRNAs als neues therapeutisches Ziel und als möglicher Biomarker

Molecular mechanisms of atrial fibrillation

Potential role of microRNAs as new therapeutic targets and potential biomarkers

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Zusammenfassung

Vorhofflimmern ist die häufigste klinische Arrhythmie, und die aktuell verfügbaren Therapien sind immer noch nicht wirklich zufriedenstellend. Die Entschlüsselung der molekularen Mechanismen soll dazu beitragen, neue Therapien zu entwickeln. Die Forschung auf dem Gebiet der microRNAs ist in den letzten Jahren in das Zentrum der kardiovaskulären Forschung gerückt. Dieser Artikel gibt eine Übersicht über die neusten Erkenntnisse bezüglich der Rolle der microRNA bei Vorhofflimmern und atrialen Remodellingprozessen sowie eine kurzen Ausblick auf die mögliche klinische Perspektive im Hinblick auf neue Therapieansätze und die potenzielle Rolle als Biomarker.

Abstract

Atrial fibrillation represents the most common form of clinical arrhythmia in daily routine. However, current therapeutic options are still limited and a better understanding of the underlying molecular mechanisms is expected to contribute to the development of new therapeutic strategies. The scientific field of microRNA research has received a lot of attention in recent years, especially regarding cardiovascular research. This article gives a brief overview of the most recent developments in microRNA research in the field of atrial fibrillation and atrial remodelling processes. Furthermore, the clinical perspective of microRNAs as new therapeutic targets and as potential biomarkers is discussed.

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Authors and Affiliations

  1. Medizinische Klinik und Poliklinik I, Klinikum der Universität München - Campus Großhadern, Marchioninistr. 15, 81377, München, Deutschland

    R. Wakili, S. Clauß & S. Kääb

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  1. R. Wakili
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  2. S. Clauß
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  3. S. Kääb
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Correspondence to R. Wakili.

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Wakili, R., Clauß, S. & Kääb, S. Molekulare Mechanismen von Vorhofflimmern. Herz 37, 166–171 (2012). https://doi.org/10.1007/s00059-012-3594-0

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