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Cytotoxicity against cholangiocarcinoma and HepG2 cell lines of lignan derivatives from Hernandia nymphaeifolia

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Abstract

Twelve lignan derivatives were synthesized from deoxypodophyllotoxin isolated from Hernandia nymphaeifolia. Cytotoxicity evaluation against cholangiocarcinoma, KKU-100, and HepG2 cell lines showed that compounds 3, 9, 10, and 13 exhibited stronger cytotoxicity than the starting material, 1, with IC50 ranging from 0.42 to 2.01 μM. Compound 10 displayed interesting activity by showing IC50 values of 0.75 and 0.46 μM against KKU-100 and HepG2 cell lines, respectively. From these observation, 10 seems to be useful as a lead compound for the development of anticancer agents.

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Acknowledgements

The Post-Doctoral Training Program from Research Affairs and Graduate School, Khon Kaen University for Jittra Suthiwong is acknowledged (Grant no. 590012). This work was supported by the Thailand Research Fund (RSA5980022), Khon Kaen University and The Center of Excellence for Innovation in Chemistry (PERCH-CIC), Office of the Higher Education Commission, Ministry of Education.

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Science, Natural Products Research Unit, The Center of Excellence for Innovation in Chemistry, Khon Kaen University, Khon Kaen, 40002, Thailand

    Jittra Suthiwong & Chavi Yenjai

  2. Department of Pharmacology, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand

    Jaroon Wandee & Veerapol Kukongviriyapan

  3. Department of Chemistry, Faculty of Science, Natural Products Research Unit, The Center of Excellence for Innovation in Chemistry, Mahasarakham University, Mahasarakham, 44150, Thailand

    Siripit Pitchuanchom

  4. Department of Biotechnology, Faculty of Science, Mahidol University, Bangkok, 10400, Thailand

    Punchapat Sojikul

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  1. Jittra Suthiwong
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  2. Jaroon Wandee
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  3. Siripit Pitchuanchom
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  4. Punchapat Sojikul
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  5. Veerapol Kukongviriyapan
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  6. Chavi Yenjai
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Correspondence to Chavi Yenjai.

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Suthiwong, J., Wandee, J., Pitchuanchom, S. et al. Cytotoxicity against cholangiocarcinoma and HepG2 cell lines of lignan derivatives from Hernandia nymphaeifolia. Med Chem Res 27, 2042–2049 (2018). https://doi.org/10.1007/s00044-018-2214-9

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  • DOI: https://doi.org/10.1007/s00044-018-2214-9

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