New series of 4(3H)-quinazolinone derivatives: syntheses and evaluation of antitumor and antiviral activities
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New series of 3-(3-trifluoromethylphenyl)-6-iodo-4(3H)-quinazolinone derivatives bearing thiosemicarbazones, pyrazoles, azomethine moieties at C-2 were synthesized. The obtained products were screened for their expected anticancer activity against; human liver cancer cell line (HepG2), breast cancer cell line (MCF-7) and human lung adenocarcinoma epithelial cell line (A549) tumor cell lines. Cytotoxicity of the synthesized compounds showed good IC50 for some products in comparison with the standard drug, doxorubicin. On the other hand, antiviral activity of the synthesized products against H5N1 showed moderate to weak activity compared to Zanamivir reference drug.
Keywords4(3H)-Quinazolinones Thiosemicarbazones Pyrazoles Schiff’s bases Antitumor activity Antiviral activity
We thank Prof. Dr. Mamdouh M. Ali, Biochemistry Department, National Research Centre, Cairo, Egypt on his help to finish the antitumor part. Also, we thank Prof. Dr. Mohamed A. Ali, Virology Laboratory and Water Pollution Department, National Research Center, Cairo, Egypt on his help to finish the antiviral part.
Compliance with ethical standards
Conflict of interest
The authors declare that they have no competing interests.
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