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Medicinal Chemistry Research

, Volume 27, Issue 2, pp 571–582 | Cite as

New series of 4(3H)-quinazolinone derivatives: syntheses and evaluation of antitumor and antiviral activities

  • Samir Y. Abbas
  • Khairy A. M. El-Bayouki
  • Wahid M. Basyouni
  • Eslam A. Mostafa
Original Research
  • 245 Downloads

Abstract

New series of 3-(3-trifluoromethylphenyl)-6-iodo-4(3H)-quinazolinone derivatives bearing thiosemicarbazones, pyrazoles, azomethine moieties at C-2 were synthesized. The obtained products were screened for their expected anticancer activity against; human liver cancer cell line (HepG2), breast cancer cell line (MCF-7) and human lung adenocarcinoma epithelial cell line (A549) tumor cell lines. Cytotoxicity of the synthesized compounds showed good IC50 for some products in comparison with the standard drug, doxorubicin. On the other hand, antiviral activity of the synthesized products against H5N1 showed moderate to weak activity compared to Zanamivir reference drug.

Keywords

4(3H)-Quinazolinones Thiosemicarbazones Pyrazoles Schiff’s bases Antitumor activity Antiviral activity 

Notes

Acknowledgements

We thank Prof. Dr. Mamdouh M. Ali, Biochemistry Department, National Research Centre, Cairo, Egypt on his help to finish the antitumor part. Also, we thank Prof. Dr. Mohamed A. Ali, Virology Laboratory and Water Pollution Department, National Research Center, Cairo, Egypt on his help to finish the antiviral part.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no competing interests.

Supplementary material

44_2017_2083_MOESM1_ESM.pdf (2.4 mb)
Supplementary Information

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Copyright information

© Springer Science+Business Media, LLC 2017

Authors and Affiliations

  • Samir Y. Abbas
    • 1
  • Khairy A. M. El-Bayouki
    • 1
  • Wahid M. Basyouni
    • 1
  • Eslam A. Mostafa
    • 1
  1. 1.Organometallic and Organometalloid Chemistry DepartmentNational Research CentreCairoEgypt

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