Medicinal Chemistry Research

, Volume 27, Issue 2, pp 512–519 | Cite as

Synthesis and antiviral study of 4-(7,7-dimethyl-4-(piperazin-1-yl)-5,6,7,8-tetrahydroquinazolin-2-yl) morpholine derivatives

  • Balaraman Selvakumar
  • Naveen Gujjar
  • Madhuri Subbiah
  • Kuppanagounder P. Elango
Original Research


A series of 4-(7,7-dimethyl-4-(piperazin-1-yl)-5,6,7,8-tetrahydroquinazolin-2-yl)morpholine substituted sulfonamide and urea derivatives has been synthesized and characterized using spectral techniques. The antiviral activity of these compounds against an avian paramyxo virus (AMPV-1) was screened using MTT assay and found that one of the sulfonamide derivatives (2d) show three-fold higher antiviral activity than Ribavirin, a commercial antiviral drug substance.

Graphical abstract

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Tetrahydroquinazoline Piperazine Morpholine Avian paramyxo virus Antiviral 



We are thankful to the Management, Anthem Biosciences, Bangalore, India, for their invaluable support and allocation of resources for this work. We would like to thank the Analytical Chemistry team of Anthem Biosciences for having carried out all the analytical work.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no competing interests.

Supplementary material

44_2017_2077_MOESM1_ESM.pdf (975 kb)
Supplementary Information


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Copyright information

© Springer Science+Business Media, LLC 2017

Authors and Affiliations

  • Balaraman Selvakumar
    • 1
  • Naveen Gujjar
    • 2
  • Madhuri Subbiah
    • 2
  • Kuppanagounder P. Elango
    • 3
  1. 1.Anthem Biosciences Pvt. Ltd.BangaloreIndia
  2. 2.National Institute of Animal BiotechnologyHyderabadIndia
  3. 3.Department of ChemistryGandhigram Rural Institute (Deemed University)GandhigramIndia

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