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A new benzofuran derivative glycoside and a new coumarin glycoside from roots of Heracleum dissectum Ledeb

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Abstract

Heracleum dissectum Ledeb. is an ethnic herb used by Oroqen people in Northeast China. The roots of this plant are usually used for treatment of several diseases. However, chemical constituents and pharmacological study were rarely reported. In this present study, phytochemical investigation of H. dissectum methanolic extract (HdME) led to the isolation of a new benzofuran derivative glycoside, 6-methoxycarbonylethyl-benzofuran-5-O-β-d-xylopyranosyl (1 → 2)-β-d-glucopyranoside (1) and a new coumarin glycoside, 6″-β-d-glucopyranosyl-apterin (2). Their structures were elucidated on the basis of physicochemical properties and the detailed interpretation of various spectroscopic data. Adipogenesis accumulating activity was assayed in 3T3-L1 cells. Compound 2 could potently accelerate the accumulation of triglycerides (TG) in 3T3-L1 adipocytes in which TG concentrations were 15.6 ± 2.3, 26.8 ± 1.8, and 35.6 ± 2.6% higher than those of the control group at the concentration of 3, 10, and 30 μM, respectively. In contrast, compound 1 exhibited comparatively weak activity on TG accumulation in adipocytes. This result denoted that the new compound 2 might possess antidiabetic activity in vivo.

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Acknowledgements

This study was partly supported by Natural Science Foundation of Shaanxi province (No. 2015JM8413) and China (No. 81673564).

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Authors and Affiliations

  1. School of Pharmacy, Xi’an Jiaotong University, Xi’an, 710061, China

    Jie Mi, Yajie Peng, Haimin Zhang, Xinrui Wang, Yayu Huo, Yang Gao & Hailong Zhang

  2. Department of Pharmaceutical Analysis, Heilongjiang University of Chinese Medicine, Harbin, 150040, China

    Zhigang Wang

  3. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China

    Ying liu

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  1. Jie Mi
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  2. Yajie Peng
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  3. Haimin Zhang
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  4. Xinrui Wang
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  5. Yayu Huo
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  6. Zhigang Wang
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  7. Ying liu
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  8. Yang Gao
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  9. Hailong Zhang
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Correspondence to Hailong Zhang.

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Mi, J., Peng, Y., Zhang, H. et al. A new benzofuran derivative glycoside and a new coumarin glycoside from roots of Heracleum dissectum Ledeb. Med Chem Res 27, 470–475 (2018). https://doi.org/10.1007/s00044-017-2073-9

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  • DOI: https://doi.org/10.1007/s00044-017-2073-9

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