Sealed tube promoted coupling of camptothecin and norcantharidin acid ester and their preliminary biological activity evaluation in vitro
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A facile synthetic method was developed for the novel acid-sensitive camptothecin norcantharidin acid ester derivatives 3 in sealed tube. This method offers several advantages including high yield and simple work procedure which can be extended for the synthesis of analogs. The new synthetic compounds 3 have shown better activity against several tumor cell lines in vitro test.
KeywordsSealed tube Camptothecin Norcantharidin Coupling Anticancer Synthesis
(3-dimethylaminopropyl) ethyl-carbodiimide monohydrochloride
I am very grateful for the finacial support from Joint fund project of Guizhou Provincial department of Science and Technology (QianKeHe LH Zi 7545), (QianKeHe LH Zi 7531), Science and Technology Department of Guizhou Province (QKHSY 2844) and (QKHSY 3030). I am also thankful for Dr. Yuqi He’s useful explanation on HPLC and LC/MS spectra data.
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Conflict of interest
The authors declare that they have no competing interests.
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