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Design and synthesis of 5-chloro-2-hydroxy-3-triazolylbenzoic acids as HIV integrase inhibitors

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Abstract

A series of potential HIV-1 integrase inhibitors based on 5-chloro-2-hydroxy-3-triazolylbenzoic acid scaffold was designed and synthesized. Some of these compounds exhibit potent inhibitory activities at micromolar concentrations against HIV-1 integrase in the 3′-end processing and the strand transfer step.

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Acknowledgments

This work was supported by Grants from the Beijing Natural Science Foundation (No. 7112008), and Fund to Zeng, C. C. from Beijing City Education Committee (KM201010005009). Zeng, C. C. thanks Ms. Chiu Marco Lam at UCSB for the languish polishing.

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Authors and Affiliations

  1. College of Life-Sciences and Bioengineering, Beijing University of Technology, Beijing, 100124, China

    Jie Chen, Cheng-Fu Liu, Cheng-Wen Yang, Cheng-Chu Zeng, Wei Liu & Li-Ming Hu

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  1. Jie Chen
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  2. Cheng-Fu Liu
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  3. Cheng-Wen Yang
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  4. Cheng-Chu Zeng
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  5. Wei Liu
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  6. Li-Ming Hu
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Correspondence to Cheng-Chu Zeng.

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Chen, J., Liu, CF., Yang, CW. et al. Design and synthesis of 5-chloro-2-hydroxy-3-triazolylbenzoic acids as HIV integrase inhibitors. Med Chem Res 24, 2950–2959 (2015). https://doi.org/10.1007/s00044-015-1325-9

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  • DOI: https://doi.org/10.1007/s00044-015-1325-9

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