Abstract
A novel class of sulfonylurea and thiourea derivatives substituted with pyridazine and triazolopyridazine were designed and synthesized. The target compounds were assayed for their effects on the insulin release of alloxan-induced diabetic rats. The results showed that derivatives 4a, 4c, 8a, 11a, and 11b have significant antihyperglycemic effect in an experimental model of diabetes mellitus. No significant differences in cholesterol levels were observed between the diabetic group and diabetic groups that received the test compounds. However, the triglycerides level was reduced significantly by compound 8a when compared with the diabetic group.
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Acknowledgments
The authors are grateful for financial support of this work at the Faculty of Science, Zagazig University, through the project “Synthesis and evaluation of some sulfonylureas as novel antidiabetic drugs.”
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Taken in part from M.Sc. thesis of Sebaey Mahgoub, Zagazig University, 2013.
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Deeb, A., El-Eraky, W., El-Awdan, S. et al. Pyridazine and its related compounds. Part 34. Hypoglycemic and hypolipidemic activity of some novel condensed pyridazine sulfonamides. Med Chem Res 23, 34–41 (2014). https://doi.org/10.1007/s00044-013-0605-5
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DOI: https://doi.org/10.1007/s00044-013-0605-5