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Developmental and functional characteristics of the thoracic aorta perivascular adipocyte

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Abstract

Thoracic aorta perivascular adipose tissue (T-PVAT) has critical roles in regulating vascular homeostasis. However, the developmental characteristics and cellular lineage of adipocyte in the T-PVAT remain unclear. We show that T-PVAT contains three long strip-shaped fat depots, anterior T-PVAT (A-T-PVAT), left lateral T-PVAT (LL-T-PVAT), and right lateral T-PVAT (RL-T-PVAT). A-T-PVAT displays a distinct transcriptional profile and developmental origin compared to the two lateral T-PVATs (L-T-PVAT). Lineage tracing studies indicate that A-T-PVAT adipocytes are primarily derived from SM22α+ progenitors, whereas L-T-PVAT contains both SM22α+ and Myf5+ cells. We also show that L-T-PVAT contains more UCP1+ brown adipocytes than A-T-PVAT, and L-T-PVAT exerts a greater relaxing effect on aorta than A-T-PVAT. Angiotensin II-infused hypertensive mice display greater macrophage infiltration into A-T-PVAT than L-T-PVAT. These combined results indicate that L-T-PVAT has a distinct development from A-T-PVAT with different cellular lineage, and suggest that L-T-PVAT and A-T-PVAT have different physiological and pathological functions.

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Acknowledgements

This work was funded by grants from the National Natural Science Foundation of China (91539202, 81570221, 81770495, 91739303, 81200067), Natural Science Foundation of Shanghai (17ZR1423800), Science and Technology Commission of Shanghai Municipality (18140903402), and Shanghai Municipal Commission of Health and Family Planning (2017YQ076, 201540222).

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Authors and Affiliations

  1. State Key Laboratory of Medical Genomics, Shanghai Key Laboratory of Hypertension, Department of Hypertension, Ruijin Hospital and Shanghai Institute of Hypertension, Shanghai Jiao Tong University School of Medicine, Shanghai, China

    Maoqing Ye, Cheng-Chao Ruan, Mengxia Fu, Lian Xu, Dongrui Chen, Dingliang Zhu & Pingjin Gao

  2. Key Laboratory of Stem Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China

    Maoqing Ye, Cheng-Chao Ruan, Dingliang Zhu & Pingjin Gao

  3. State Key Laboratory of Pharmaceutical Biotechnology and Model Animal Research Center and MOE Key Laboratory of Model Animal for Disease Study, Nanjing University, Nanjing, China

    Minsheng Zhu

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  1. Maoqing Ye
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Ye, M., Ruan, CC., Fu, M. et al. Developmental and functional characteristics of the thoracic aorta perivascular adipocyte. Cell. Mol. Life Sci. 76, 777–789 (2019). https://doi.org/10.1007/s00018-018-2970-1

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  • DOI: https://doi.org/10.1007/s00018-018-2970-1

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