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Molecular components and polarity of radial glial cells during cerebral cortex development

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Abstract

Originating from ectodermal epithelium, radial glial cells (RGCs) retain apico-basolateral polarity and comprise a pseudostratified epithelial layer in the developing cerebral cortex. The apical endfeet of the RGCs faces the fluid-filled ventricles, while the basal processes extend across the entire cortical span towards the pial surface. RGC functions are largely dependent on this polarized structure and the molecular components that define it. In this review, we will dissect existing molecular evidence on RGC polarity establishment and during cerebral cortex development and provide our perspective on the remaining key questions.

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Acknowledgements

This work is supported by Children’s Mercy-Kansas City Children’s Research Institute. The authors would also like to acknowledge the editing services of the Medical Writing Center at Children’s Mercy-Kansas City for reviewing the manuscript.

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Authors and Affiliations

  1. Department of Pediatrics, University of Kansas Medical Center, 3901 Rainbow Blvd., Kansas City, KS, 66160, USA

    Fu-Sheng Chou & Pei-Shan Wang

  2. Department of Pediatrics, University of Missouri-Kansas City, Kansas City, MO, USA

    Fu-Sheng Chou

  3. Division of Neonatology, Children’s Mercy-Kansas City, Kansas City, MO, USA

    Fu-Sheng Chou

  4. Department of Cell Biology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA

    Rong Li

Authors
  1. Fu-Sheng Chou
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  2. Rong Li
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  3. Pei-Shan Wang
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Correspondence to Pei-Shan Wang.

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Chou, FS., Li, R. & Wang, PS. Molecular components and polarity of radial glial cells during cerebral cortex development. Cell. Mol. Life Sci. 75, 1027–1041 (2018). https://doi.org/10.1007/s00018-017-2680-0

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  • DOI: https://doi.org/10.1007/s00018-017-2680-0

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