Cellular and Molecular Life Sciences

, Volume 74, Issue 23, pp 4321–4328 | Cite as

Periostin in the pathogenesis of skin diseases

  • Hiroyuki Murota
  • Yang Lingli
  • Ichiro Katayama
Multi-author review


Skin is an organ that is susceptible to damage by external injury, chronic inflammation, and autoimmunity. Tissue damage causes alterations in both the configuration and type of cells in lesional skin. This phenomenon, called tissue remodeling, is a universal biological response elicited by programmed cell death, inflammation, immune disorders, and tumorigenic, tumor proliferative, and cytoreductive activity. In this process, changes in the components of the extracellular matrix are required to provide an environment that facilitates tissue remodeling. Among these extracellular matrix components, periostin, a glycoprotein that is predominantly secreted from dermal fibroblasts, has attracted attention. Periostin localizes in the papillary dermis of normal skin, and is aberrantly expressed in the dermis of lesional skin in atopic dermatitis, scar, systemic/limited scleroderma, melanoma, cutaneous T cell lymphoma, and skin damage caused by allergic/autoimmune responses. Periostin induces processes that result in the development of dermal fibrosis, and activate or protract the immune response. The aim of this review was to summarize recent knowledge of the role of periostin in the pathogenesis of dermatoses, and to explore whether periostin is a potential therapeutic target for skin diseases.


Skin diseases Periostin Scleroderma Atopic dermatitis Melanoma Scar Mycosis fungoides 


Compliance with ethical standards

Conflict of interest

The authors declare no conflicts of interest.


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© Springer International Publishing AG 2017

Authors and Affiliations

  1. 1.Department of Dermatology, Course of Integrated Medicine, Graduate School of MedicineOsaka UniversitySuitaJapan

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