Cellular and Molecular Life Sciences

, Volume 74, Issue 23, pp 4259–4268 | Cite as

Introductory review: periostin—gene and protein structure

Multi-author review


Although many studies have described the role of periostin in various diseases, the function of the periostin protein structures derived from alternative splicing and proteinase cleavage at the C-terminal remain unknown. Further experiments revealing the protein structures that are highly related to diseases are essential to understand the function of periostin in depth, which would accelerate its clinical application by establishing new approaches for curing intractable diseases. Furthermore, this understanding would enhance our knowledge of novel functions of periostin related to stemness and response to mechanical stress.


Periostin fas 1 family Matricellular protein Alternative splicing Proteinase cleavage 



I thank my collaborators involved in the periostin project for providing figures.


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© Springer International Publishing AG 2017

Authors and Affiliations

  1. 1.International FrontierTokyo Institute of TechnologyTokyoJapan
  2. 2.Department of Pharmacology, School of DentistryShowa UniversityTokyoJapan

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