Cellular and Molecular Life Sciences

, Volume 74, Issue 15, pp 2749–2760 | Cite as

S100A6 protein: functional roles

  • Rosario Donato
  • Guglielmo Sorci
  • Ileana Giambanco


S100A6 protein belongs to the A group of the S100 protein family of Ca2+-binding proteins. It is expressed in a limited number of cell types in adult normal tissues and in several tumor cell types. As an intracellular protein, S100A6 has been implicated in the regulation of several cellular functions, such as proliferation, apoptosis, the cytoskeleton dynamics, and the cellular response to different stress factors. S100A6 can be secreted/released by certain cell types which points to extracellular effects of the protein. RAGE (receptor for advanced glycation endproducts) and integrin β1 transduce some extracellular S100A6’s effects. Dosage of serum S100A6 might aid in diagnosis in oncology.


S100A6 protein Proliferation Migration/motility Cancer Invasion Cytoskeleton Receptor 



Amyotrophic lateral sclerosis


Calcyclin-binding protein/Siah-1-interacting protein


Cyclin-dependent kinase


Epidermal growth factor


Heat shock protein




Transformed mouse 3T3 cell double minute


Nuclear transcription factor κB


Nf-E2 related factor 2


Platelet-derived growth factor


Receptor for advanced glycation end product


Reactive oxygen species


Superoxide dismutase


Specificity protein 1


Tumor necrosis factor


Tumor necrosis factor-related apoptosis-inducing ligand


Upstream transcription factor


Vascular endothelial growth factor



This work was supported by Associazione Italiana Ricerca sul Cancro (Project No. Project 17581). The authors wish to thanks the reviewers for criticism and suggestions.


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Copyright information

© Springer International Publishing 2017

Authors and Affiliations

  • Rosario Donato
    • 1
    • 2
  • Guglielmo Sorci
    • 1
    • 2
  • Ileana Giambanco
    • 1
  1. 1.Department of Experimental Medicine, Centro Universitario per la Ricerca sulla Genomica Funzionale, Perugia Medical SchoolUniversity of PerugiaPerugiaItaly
  2. 2.Department of Experimental Medicine, Istituto Interuniversitario di Miologia (Interuniversity Institute for Myology), Perugia Medical SchoolUniversity of PerugiaPerugiaItaly

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