Cellular and Molecular Life Sciences

, Volume 74, Issue 15, pp 2773–2782 | Cite as

Development of anticancer agents targeting the Hedgehog signaling



Hedgehog signaling is an evolutionarily conserved pathway which is essential in embryonic and postnatal development as well as adult organ homeostasis. Abnormal regulation of Hedgehog signaling is implicated in many diseases including cancer. Consequently, substantial efforts have made in the past to develop potential therapeutic agents that specifically target the Hedgehog signaling for cancer treatment. Here, we review the therapeutic agents for inhibition of the Hedgehog signaling and their clinical advances in cancer treatment.


Hedgehog signaling Patched Smothern Cancer Small molecules Therapeutic Drugs Safety and clinic 



This work was supported by the seed fund of College of Veterinary Medicine at Western University of Health Sciences and Faculty Development Grant from Chinese American Faculty Association of Southern California (CAFA). The authors would like to acknowledge ChemAxon ( for providing an academic license to their software.

Compliance with ethical standards

Conflict of interest

The authors declare that there are no conflicts of interest.


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Copyright information

© Springer International Publishing 2017

Authors and Affiliations

  • Xiangqian Zhang
    • 1
  • Ye Tian
    • 1
  • Yanling Yang
    • 2
  • Jijun Hao
    • 3
    • 4
  1. 1.College of Life ScienceYan’an UniversityYan’anChina
  2. 2.Medical CollegeYan’an UniversityYan’anChina
  3. 3.College of Veterinary MedicineWestern University of Health SciencesPomonaUSA
  4. 4.Graduate College of Biomedical SciencesWestern University of Health SciencesPomonaUSA

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