Fig. 2 | Cellular and Molecular Life Sciences

Fig. 2

From: Bafilomycin A1 activates respiration of neuronal cells via uncoupling associated with flickering depolarization of mitochondria

Fig. 2

The effect of Baf on generation of ROS and apoptosis of dPC12 cells. a FACS analysis of ROS-sensitive carboxy-H2DCFDA probe fluorescence reveal an increase in ROS levels in the cells treated with Baf and CMA (both 0.25 μM) for 2 h. b Quantitative analysis of data presented in a as compared to the effect of classical ROS inducer tert-butyl hydroperoxide (TBHP, 250 μM). c Caspase-3 activity was increased in the cells treated with both V-ATPase inhibitors for 4 h; however, the effect of Baf was significantly stronger. Asterisks significant differences

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