Advertisement

Inflammation Research

, Volume 49, Issue 3, pp 123–127 | Cite as

The effects of contignasterol (IZP-94,005) on allergen-induced plasma protein exudation in the tracheobronchial airways of sensitized guinea - pigs in vivo

  • F.R. Coulson
  • S.R. O'Donnell

Abstract.

Objective: To examine contignasterol (marine-derived) on allergen-induced plasma exudation in the tracheobronchial airways.¶Material: English shorthair guinea-pigs actively sensitized to ovalbumin.¶Treatment: 21 to 36 days after sensitization, contignasterol, budesonide or nedocromil and then ovalbumin (12 pmol) were superfused onto the tracheal mucosa (i.t.) of anaesthetized animals.¶Methods: Tracer (125I-human serum albumin) was measured in tracheobronchial lavage.¶Results: Thirty min after administration of contignasterol (100 and 200, but not 0.2 or 2.0 μg/kg), budesonide or nedocromil (200 μg/kg), the ovalbumin response (plasma exudate, μl) was significantly inhibited. The response was also inhibited 5 min after 200 μg/kg nedocromil but not after contignasterol or budesonide.¶Conclusions: Contignasterol was topically active and showed anti-inflammatory effects in the tracheobronchial airways in that it inhibited allergen-induced plasma protein exudation.

Key words: Contignasterol — Allergen — Plasma protein exudation — Budesonide — Nedocromil 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Copyright information

© Birkhäuser Verlag, 2000

Authors and Affiliations

  • F.R. Coulson
    • 1
  • S.R. O'Donnell
    • 1
  1. 1.Pulmonary Pharmacology Group, Department of Physiology and Pharmacology, The University of Queensland, Brisbane QLD 4072, Australia, Fax +61 733 652 299, e-mail: odonnell@plpk.uq.edu.au AU

Personalised recommendations