The effects of contignasterol (IZP-94,005) on allergen-induced plasma protein exudation in the tracheobronchial airways of sensitized guinea - pigs in vivo

Abstract.

Objective: To examine contignasterol (marine-derived) on allergen-induced plasma exudation in the tracheobronchial airways.¶Material: English shorthair guinea-pigs actively sensitized to ovalbumin.¶Treatment: 21 to 36 days after sensitization, contignasterol, budesonide or nedocromil and then ovalbumin (12 pmol) were superfused onto the tracheal mucosa (i.t.) of anaesthetized animals.¶Methods: Tracer (¹²⁵I-human serum albumin) was measured in tracheobronchial lavage.¶Results: Thirty min after administration of contignasterol (100 and 200, but not 0.2 or 2.0 μg/kg), budesonide or nedocromil (200 μg/kg), the ovalbumin response (plasma exudate, μl) was significantly inhibited. The response was also inhibited 5 min after 200 μg/kg nedocromil but not after contignasterol or budesonide.¶Conclusions: Contignasterol was topically active and showed anti-inflammatory effects in the tracheobronchial airways in that it inhibited allergen-induced plasma protein exudation.