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Inflammation Research

, Volume 46, Issue 10, pp 409–411 | Cite as

Immunohistochemical characterization of HSP, α-MSH, Merkel cells and neuronal markers in acute UV dermatitis and acute contact dermatitis in vivo

  • C. Bayerl
  • J. Lauk
  • I. Moll
  • E. G. Jung

Abstract.

Objective: To study the immunoneurocrine network in inflammatory dermatoses, we investigated histochemically acute UV and acute contact dermatitis.¶Methods: Antibodies were applied to frozen and paraffin specimens of human skin after irradiation (n = 10), to positive patch tests (n = 10) and controls (n = 10) against: HSP 70, 72, 27, neuronal polypeptides (α-MSH, NSE, bombesin, PGP 9.5, NGF, NGF-R) and intermediate filaments (peripherin, NF 200, CK 19, 20).¶Results: HSPs and α-MSH were upregulated in UV dermatitis in the epidermis compared to contact dermatitis and normal skin. Sunburn cells did not express HSPs or α-MSH in UV dermatitis. Neuronal markers and HSP 27 labeled more nerve fibers in UV than in contact dermatitis, except the increased staining for NGF, NGF-R and α-MSH in nerve fibers in contact dermatitis. In UV dermatitis, 50% of Merkel cells were suprabasal, but in contact dermatitis, basal, rounded and reduced in number.¶Conclusions: Merkel cells, HSPs and markers of neuroinflammation are of different importance in UV and contact dermatitis in vivo.

Key words: HSP —α-MSH — Merkel cells — UV dermatitis — Contact dermatitis 

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Copyright information

© Birkhäuser Verlag, Basel, 1997

Authors and Affiliations

  • C. Bayerl
    • 1
  • J. Lauk
    • 1
  • I. Moll
    • 1
  • E. G. Jung
    • 1
  1. 1.Department of Dermatology, Mannheim Medical School, University of Heidelberg, Theodor-Kutzer-Ufer, D-68167 Mannheim, Germany, Fax +49 621 383 3815, e-mail: christiane.bayerl@haut.ma.uni-heidelberg.deDE

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