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miR-196a2 (rs11614913) polymorphism is associated with coronary artery disease, but not with in-stent coronary restenosis

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Abstract

Objective

The aim of the study was to evaluate the association of miRNA-146a G/C (rs2910164), and miRNA-196a2 C/T (rs11614913) polymorphisms with the presence of coronary artery disease (CAD) and/or restenosis in patients with coronary stent.

Materials and methods

The polymorphisms were determined in 218 patients with CAD who underwent coronary artery stenting (66 with restenosis and 152 without restenosis) and 611 healthy controls using 5′ exonuclease TaqMan assays.

Results

The distribution of both polymorphisms was similar in patients with and without restenosis. However, when the whole group of patients (with and without restenosis) was compared to healthy controls, under co-dominant, dominant and additive genetic models, the T allele of the miRNA-196a2 C/T (rs11614913) polymorphism was associated with increased risk of CAD (OR = 2.18, Pco–dom = 0.006, OR = 1.86, Pdom = 0.002, and OR = 1.52, Padd = 0.002, respectively). All models were adjusted for age, type 2 diabetes mellitus, dyslipidemia, hypertension and smoking habit. The “GT” haplotype was associated with increased risk of developing CAD (OR = 1.36, P = 0.046).

Conclusions

Our data suggests that the T allele of the miRNA-196a2 C/T (rs11614913) polymorphism is associated with the risk of developing CAD, but no association with restenosis was observed.

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Acknowledgements

This work was supported in part by grants from the Consejo Nacional de Ciencia y Tecnología (Project number 233277), Mexico City, Mexico. The authors are grateful to the study participants. Institutional Review Board approval was obtained for all sample collections. The authors are grateful to Marva Ilian Arellano Gonzalez for her technical assistance.

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Author notes

  1. José Manuel Fragoso and Julian Ramírez-Bello are equal and the order of authorship is arbitrary.

Authors and Affiliations

  1. Department of Molecular Biology, Instituto Nacional de Cardiología Ignacio Chávez, Juan Badiano 1, Sección XVI, Del. Tlalpan, 14080, Mexico City, Mexico

    José Manuel Fragoso & Gilberto Vargas-Alarcón

  2. Endocrine and Metabolic Diseases Research Unit, Hospital Juárez de Mexico, Mexico City, Mexico

    Julian Ramírez-Bello & Mayra Jiménez-Morales

  3. Interventional Cardiology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico

    Marco Antonio Martínez-Ríos, Marco Antonio Peña-Duque & Hilda Delgadillo-Rodríguez

  4. Department of Endocrinology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico

    Rosalinda Posadas-Sánchez & Carlos Posadas-Romero

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  1. José Manuel Fragoso
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Correspondence to Gilberto Vargas-Alarcón.

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Fragoso, J.M., Ramírez-Bello, J., Martínez-Ríos, M.A. et al. miR-196a2 (rs11614913) polymorphism is associated with coronary artery disease, but not with in-stent coronary restenosis. Inflamm. Res. 68, 215–221 (2019). https://doi.org/10.1007/s00011-018-1206-z

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