Baicalin in flavocoxid may act against hepatitis B virus via a pro-inflammatory pathway
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The recent paper by Pollicino and colleagues showed that a new synthetic flavonoid formula (Flavocoxid) containing baicalin and catechin has a potent antiviral activity against hepatitis B virus (HBV) infection . Flavocoxid (FLAV), which is known to be an anti-inflammatory natural product [2, 3], is a FDA-regulated proprietary blend of purified plant-derived flavonoids (Limbrel®) for use as a supplementary nutraceutical in clinical nutrition studies and contains baicalein-7-O-glucuronide and catechins .
It is well known that baicalin inhibits the HBV viral RNA . This flavone-glucuronide dampens dose-dependently the production of HBV 2.1, 2.4 and 3.5 kb HBV RNAs, the latter being the template for the synthesis of HBV DNA . Furthermore, catechins are able to inhibit HBV infection via further biochemical pathways [5, 6, 7]. It is not so surprising, therefore, that FLAV may act against HBV, blunting the replication of viral DNA and targeting other vital steps...
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The author states he has no conflict of interest.
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