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The gestational power of mast cells in the injured tissue

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Abstract

The inflammatory response expressed after wound healing would be the recapitulation of systemic extra-embryonic functions, which would focus on the interstitium of the injured tissue. In the injured tissue, mast cells, provided for a great functional heterogeneity, could play the leading role in the re-expression of extra-embryonic functions, i.e., coelomic–amniotic and trophoblastic–vitelline. Moreover, mast cells would favor the production of a gastrulation-like process, which in certain tissues and organs would induce the regeneration of the injured tissue. Therefore, the engraftment of mesenchymal stem cells and mast cells, both with an extra-embryonic regenerative phenotype, would achieve a blastema, from the repaired and regenerated injured tissue, rather than by fibrosis, which is commonly made through wound-healing.

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Authors and Affiliations

  1. Department of Surgery, School of Medicine, Complutense University of Madrid, Plaza de Ramón y Cajal s.n., 28040, Madrid, Spain

    Maria-Angeles Aller & Jaime Arias

  2. UCL Division of Medicine, Institute for Liver and Digestive Health, Rowland Hill Street, London, NW32PF, UK

    Natalia Arias

  3. INEUROPA, Instituto de Neurociencias del Principado de Asturias, Oviedo, Spain

    Natalia Arias

  4. Department of Cell Biology, Physiology and Immunology, Veterinary School, Autonoma University of Barcelona, Cerdanyola del Vallès, 08193, Barcelona, Spain

    Vicente Martínez & Patri Vergara

  5. Biomedical Research Center for Hepatic and Digestive Illnesses (CIBERehd), Carlos II Health Institute, Barcelona, Spain

    Patri Vergara

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  1. Maria-Angeles Aller
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  2. Natalia Arias
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  3. Vicente Martínez
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Correspondence to Maria-Angeles Aller.

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Aller, MA., Arias, N., Martínez, V. et al. The gestational power of mast cells in the injured tissue. Inflamm. Res. 67, 111–116 (2018). https://doi.org/10.1007/s00011-017-1108-5

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