Inflammation Research

, Volume 67, Issue 2, pp 107–109 | Cite as

Insulin-like growth factor-6 (IGFBP-6) stimulates neutrophil oxidative burst, degranulation and chemotaxis

  • Massimo Conese
  • Susanna D’Oria
  • Stefano Castellani
  • Rosa Trotta
  • Pasqualina Montemurro
  • Arcangelo Liso
Short Communication


The aim of this study was to understand whether insulin-like growth factor-binding protein-6 (IGFBP-6) has functional effects on neutrophils, in particular when they cross epithelium during inflammation. We found that IGFBP-6 increased ROS production (cytofluorimetry), degranulation of primary and tertiary granules (ELISA) and transmigration through the epithelial monolayer. No priming by IGFBP-6 on neutrophils stimulated by either PMA or fMLP was observed. IGFBP-6 is an agonist of neutrophils’ functions, most likely when these cells have been already activated by other stimuli.


Neutrophils IGFBP-6 Oxidative burst Degranulation Chemotaxis 



This work was in part funded by Associazione Italiana contro le Leucemie-Linfomi e Mieloma (Section of Foggia) (A. Liso). S. Castellani is a researcher funded by Intervento Cofinanziato dal Fondo di Sviluppo e Coesione 2007–2013—APQ Ricerca Regione Puglia “Programma regionale a sostegno della specializzazione intelligente e delle sostenibilità sociale ed ambientali—Future In Research”.


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Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  1. 1.Department of Medical and Surgical SciencesUniversity of FoggiaFoggiaItaly
  2. 2.Section of General Pathology, Department of Biomedical Sciences and Human OncologyUniversity of BariBariItaly

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