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Inflammation Research

, Volume 62, Issue 8, pp 791–795 | Cite as

Lack of association between IL-23R gene polymorphisms and systemic lupus erythematosus in a Chinese population

  • Gui-Mei Chen
  • Chen-Chen Feng
  • Qian-Ling Ye
  • Juan Wang
  • Han Cen
  • Rui Li
  • Hui Peng
  • Mo Zhou
  • Rui-Xue Leng
  • Yin-Guang Fan
  • Jin-Hui Tao
  • Hai-Feng Pan
  • Dong-Qing Ye
Original Research Paper

Abstract

Objective

The aim to this study was to investigate the association between the single-nucleotide polymorphisms (SNPs) of interleukin (IL)-23 receptor gene and systemic lupus erythematosus (SLE) in a Chinese population.

Methods

A case–control study was performed to investigate the associations of SNPs in IL-23R gene (rs10889677 and rs1884444) with susceptibility to SLE in 521 Chinese SLE patients and 527 normal controls. The chi-square test and unconditional Logistic regression were used to analysis by SPSS 10.1 software.

Results

No significant differences were detected for the distribution of allele and genotype frequencies of these two SNPs between patients and controls as well as SLE patients with nephritis (LN) and those without nephritis.

Conclusion

The findings suggest that the polymorphisms of IL-23R gene might not contribute to the susceptibility of SLE in the Chinese population.

Keywords

Systemic lupus erythematosus IL-23R gene Polymorphism Chinese population 

Notes

Acknowledgments

This work was supported by the National Natural Science Foundation of China (81172764, 30830089), the Specialized Research Fund for the Doctoral Program of Higher Education of China (20113420110005) and School Research Fund of Anhui Medical University (2010xkj012). We wish to thank the patients and normal controls for their cooperation.

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Copyright information

© Springer Basel 2013

Authors and Affiliations

  • Gui-Mei Chen
    • 1
    • 2
  • Chen-Chen Feng
    • 1
    • 2
  • Qian-Ling Ye
    • 3
  • Juan Wang
    • 1
    • 2
  • Han Cen
    • 1
    • 2
  • Rui Li
    • 1
    • 2
  • Hui Peng
    • 1
    • 2
  • Mo Zhou
    • 1
    • 2
  • Rui-Xue Leng
    • 1
    • 2
  • Yin-Guang Fan
    • 1
    • 2
  • Jin-Hui Tao
    • 4
  • Hai-Feng Pan
    • 1
    • 2
  • Dong-Qing Ye
    • 1
    • 2
  1. 1.Department of Epidemiology and Biostatistics, School of Public HealthAnhui Medical UniversityHefeiPeople’s Republic of China
  2. 2.Anhui Provincial Laboratory of Population Health and Major Disease Screening and DiagnosisHefeiPeople’s Republic of China
  3. 3.Department of HematologyThe Second Affiliated Hospital of Anhui Medical UniversityHefeiPeople’s Republic of China
  4. 4.Department of Rheumatology and ImmunologyAnhui Provincial HospitalHefeiPeople’s Republic of China

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