Inflammation Research

, Volume 61, Issue 12, pp 1295–1297 | Cite as

Decrease of cerebral mast cell degranulation after systemic administration of lipopolysaccharide

  • David Dubayle
  • Anne Héron
Short Communication



The mast cell is an immunocyte, but its functions in the brain remain unclear.

Materials and methods

In a rat model of weak inflammation, we analyzed the effect of a gram-negative bacterial lipopolysaccharide injection (100 μg/kg) on thalamic mast cell (MC) population.


We demonstrate a significant decrease of their degranulation, which suggests the implication of MC in preventing sepsis on the brain.


Mast cells LPS Brain Rat 


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Copyright information

© Springer Basel 2012

Authors and Affiliations

  1. 1.Laboratory of Neurophysics and Physiology, CNRS UMR 8119Paris Descartes UniversityParisFrance
  2. 2.Experimental, Metabolic and Clinical Biology Department, Faculty of Phamaceutical SciencesParis Descartes UniversityParisFrance

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