Inflammation Research

, Volume 61, Issue 7, pp 657–663 | Cite as

Associations between interleukin-10 polymorphisms and susceptibility to psoriasis: a meta-analysis

  • Young Ho Lee
  • Sung Jae Choi
  • Jong Dae Ji
  • Gwan Gyu Song
Original Research Paper



The aim of this study was to determine whether three specific interleukin-10 (IL-10) polymorphisms confer susceptibility to psoriasis.


A meta-analysis was conducted on the associations between the IL-10-1082 G/A, -592 C/A polymorphisms and haplotypes of the IL-10-1082 G/A, -592 C/A, -819 C/T polymorphisms and psoriasis.


A total of eight studies involving 1,018 psoriasis patients and 1,186 controls were considered in the meta-analysis. No association was found between psoriasis and the IL-10-1082 G allele in all study subjects [odds ratio (OR) = 1.098, 95 % confidence interval (CI) = 0.923−1.306, p = 0.291] or between this allele and psoriasis in Europeans (OR = 0.990, 95 % CI = 0.809−1.214, p = 0.925), but a significant association was found in Asians (OR = 1.785, 95 % CI = 1.144−2.76, p = 0.011). Three polymorphisms at the promoter region of IL-10 (-1082 G/A, -819 C/T, -592 C/A) are known to be in complete linkage disequilibrium, but no association was found between the haplotype and psoriasis.


This meta-analysis shows that the IL-10-1082 G/A polymorphism confers susceptibility to psoriasis in Asians, and suggests that the IL-10 promoter -1082 polymorphism has an ethnicity-specific effect.


Psoriasis Interleukin-10 Polymorphism Meta-analysis 


Conflict of interest

The authors have no financial or non-financial conflict of interest to declare.


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Copyright information

© Springer Basel AG 2012

Authors and Affiliations

  • Young Ho Lee
    • 1
  • Sung Jae Choi
    • 1
  • Jong Dae Ji
    • 1
  • Gwan Gyu Song
    • 1
  1. 1.Division of Rheumatology, Department of Internal MedicineKorea University Anam Hospital, Korea University College of MedicineSeoulKorea

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