Lack of association between plasma myeloperoxidase levels and angiographic severity of coronary artery disease in patients with acute coronary syndrome
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To evaluate the association between plasma myeloperoxidase (MPO) levels and angiographic severity of coronary atherosclerotic lesions in patients with non-ST elevation acute coronary syndrome (ACS).
Design and methods
This cross-sectional study examined high-risk ACS patients who underwent coronary angiography within 72 h of the onset of symptoms by measuring their plasma MPO levels after sheath insertion. Gensini score was used to evaluate angiographic severity of coronary artery disease.
A total of 48 patients were included in the study. Median MPO levels and Gensini scores were 6.9 ng/mL (4.4–73.5 ng/mL) and 10 (0–87.5), respectively. Spearman’s correlation coefficient did not show a significant association between MPO levels and Gensini scores (r s = 0.2; p = 0.177). There was no correlation between MPO and age, hypertension, diabetes, leukocyte count, troponin I, CK-MB ≥2 × ULN (upper limit of normal), TIMI risk score ≥4 and Gensini score in the multivariate analysis.
Our findings indicate that MPO expression is not associated with anatomical severity of coronary lesions in ACS.
KeywordsAtherosclerosis Inflammation Biomarkers
- 15.Morrow DA, Sabatine MS, Brennan ML, et al. Concurrent evaluation of novel cardiac biomarkers in acute coronary syndrome: myeloperoxidase and soluble CD40 ligand and the risk of recurrent ischaemic events in TACTICS-TIMI 18. Eur Heart J 2008;29:1096–12.Google Scholar
- 31.Fragmin and Fast Revascularization during InStability in Coronary artery disease Investigators. Invasive compared with non-invasive treatment in unstable coronary artery disease: FRISC II prospective randomised multicentre study. Lancet 1999;354:708–15.Google Scholar