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Inflammation Research

, Volume 60, Issue 2, pp 137–142 | Cite as

Lack of association between plasma myeloperoxidase levels and angiographic severity of coronary artery disease in patients with acute coronary syndrome

  • Eraldo de Azevedo Lucio
  • Sandro C. Gonçalves
  • Jorge P. Ribeiro
  • Gilberto L. Nunes
  • Jarbas R. de Oliveira
  • Gustavo N. Araujo
  • Marco V. Wainstein
Original Research Paper

Abstract

Objective

To evaluate the association between plasma myeloperoxidase (MPO) levels and angiographic severity of coronary atherosclerotic lesions in patients with non-ST elevation acute coronary syndrome (ACS).

Design and methods

This cross-sectional study examined high-risk ACS patients who underwent coronary angiography within 72 h of the onset of symptoms by measuring their plasma MPO levels after sheath insertion. Gensini score was used to evaluate angiographic severity of coronary artery disease.

Results

A total of 48 patients were included in the study. Median MPO levels and Gensini scores were 6.9 ng/mL (4.4–73.5 ng/mL) and 10 (0–87.5), respectively. Spearman’s correlation coefficient did not show a significant association between MPO levels and Gensini scores (r s = 0.2; p = 0.177). There was no correlation between MPO and age, hypertension, diabetes, leukocyte count, troponin I, CK-MB ≥2 × ULN (upper limit of normal), TIMI risk score ≥4 and Gensini score in the multivariate analysis.

Conclusion

Our findings indicate that MPO expression is not associated with anatomical severity of coronary lesions in ACS.

Keywords

Atherosclerosis Inflammation Biomarkers 

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Copyright information

© Springer Basel AG 2010

Authors and Affiliations

  • Eraldo de Azevedo Lucio
    • 1
    • 3
  • Sandro C. Gonçalves
    • 1
  • Jorge P. Ribeiro
    • 1
    • 2
  • Gilberto L. Nunes
    • 1
    • 3
  • Jarbas R. de Oliveira
    • 4
  • Gustavo N. Araujo
    • 2
  • Marco V. Wainstein
    • 1
    • 2
  1. 1.Post-graduate Program in Cardiology, Faculty of MedicineFederal University of Rio Grande do SulPorto AlegreBrazil
  2. 2.Cardiology DivisionHospital de Clinicas de Porto AlegrePorto AlegreBrazil
  3. 3.Hospital São Francisco da Santa Casa de Porto AlegrePorto AlegreBrazil
  4. 4.Pontifícia Universidade Católica do Rio Grande do SulPorto AlegreBrazil

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