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Lack of association between plasma myeloperoxidase levels and angiographic severity of coronary artery disease in patients with acute coronary syndrome

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Abstract

Objective

To evaluate the association between plasma myeloperoxidase (MPO) levels and angiographic severity of coronary atherosclerotic lesions in patients with non-ST elevation acute coronary syndrome (ACS).

Design and methods

This cross-sectional study examined high-risk ACS patients who underwent coronary angiography within 72 h of the onset of symptoms by measuring their plasma MPO levels after sheath insertion. Gensini score was used to evaluate angiographic severity of coronary artery disease.

Results

A total of 48 patients were included in the study. Median MPO levels and Gensini scores were 6.9 ng/mL (4.4–73.5 ng/mL) and 10 (0–87.5), respectively. Spearman’s correlation coefficient did not show a significant association between MPO levels and Gensini scores (r s = 0.2; p = 0.177). There was no correlation between MPO and age, hypertension, diabetes, leukocyte count, troponin I, CK-MB ≥2 × ULN (upper limit of normal), TIMI risk score ≥4 and Gensini score in the multivariate analysis.

Conclusion

Our findings indicate that MPO expression is not associated with anatomical severity of coronary lesions in ACS.

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References

  1. Libby P, Ridker PM, Maseri A. Inflammation and atherosclerosis. Circulation. 2002;105:1135–43.

    Article  CAS  PubMed  Google Scholar 

  2. de Servi S, Mazzone A, Ricevuti G, et al. Expression of neutrophil and monocyte CD11B/CD18 adhesion molecules at different sites of the coronary tree in unstable angina pectoris. Am J Cardiol. 1996;78:564–8.

    Article  PubMed  Google Scholar 

  3. Buffon A, Biasucci LM, Liuzzo G, D’Onofrio G, Crea F, Maseri A. Widespread coronary inflammation in unstable angina. N Engl J Med. 2002;347:5–12.

    Article  PubMed  Google Scholar 

  4. Naruko T, Ueda M, Haze K, et al. Neutrophil infiltration of culprit lesions in acute coronary syndromes. Circulation. 2002;106:2894–900.

    Article  PubMed  Google Scholar 

  5. Nicholls SJ, Hazen SL. Myeloperoxidase and cardiovascular disease. Arterioscler Thromb Vasc Biol. 2005;25:1102–11.

    Article  CAS  PubMed  Google Scholar 

  6. Klebanoff SJ. Myeloperoxidase: friend and foe. J Leukoc Biol. 2005;77:598–625.

    Article  CAS  PubMed  Google Scholar 

  7. Podrez EA, Abu-Soud HM, Hazen SL. Myeloperoxidase-generated oxidants and atherosclerosis. Free Radic Biol Med. 2000;28:1717–25.

    Article  CAS  PubMed  Google Scholar 

  8. Brennan ML, Hazen SL. Emerging role of myeloperoxidase and oxidant stress markers in cardiovascular risk assessment. Curr Opin Lipidol. 2003;14:353–9.

    Article  CAS  PubMed  Google Scholar 

  9. Hazen SL. Myeloperoxidase and plaque vulnerability. Arterioscler Thromb Vasc Biol. 2004;24:1143–6.

    Article  CAS  PubMed  Google Scholar 

  10. Shabani F, McNeil J, Tippett L. The oxidative inactivation of tissue inhibitor of metalloproteinase-1 (TIMP-1) by hypochlorous acid (HOCL) is suppressed by anti-rheumatic drugs. Free Radical Res. 1998;28:115–23.

    Article  CAS  Google Scholar 

  11. Fu X, Kassim SY, Parks WC, Heinecke JW. Hypochlorous acid oxygenates the cysteine switch domain of pro-matrilysin (MMP-7): a mechanism for matrix metalloproteinase activation and atherosclerotic plaque rupture by myeloperoxidase. J Bio Chem. 2001;276:41279–87.

    Article  CAS  Google Scholar 

  12. Brennan ML, Penn MS, Van Lente S, et al. Prognostic value of myeloperoxidase in patients with chest pain. N Engl J Med. 2003;349:1595–604.

    Article  CAS  PubMed  Google Scholar 

  13. Baldus S, Heeschen C, Meinertz T, et al. Myeloperoxidase serum levels predict risk in patients with acute coronary syndromes. Circulation. 2003;108:1440–5.

    Article  CAS  PubMed  Google Scholar 

  14. Cavusoglu E, Ruwend C, Eng C, et al. Usefulness of baseline plasma myeloperoxidase levels as an independent predictor of myocardial infarction at two years in patients presenting with acute coronary syndrome. Am J Cardiol. 2007;99:1364–8.

    Article  CAS  PubMed  Google Scholar 

  15. Morrow DA, Sabatine MS, Brennan ML, et al. Concurrent evaluation of novel cardiac biomarkers in acute coronary syndrome: myeloperoxidase and soluble CD40 ligand and the risk of recurrent ischaemic events in TACTICS-TIMI 18. Eur Heart J 2008;29:1096–12.

    Google Scholar 

  16. Mocatta TJ, Pilbrow AP, Cameron VA, et al. Plasma concentrations of myeloperoxidase predict mortality after myocardial infarction. J Am Coll Cardiol. 2007;49:1993–2000.

    Article  CAS  PubMed  Google Scholar 

  17. Khan SQ, Kelly D, Quinn P, Davies JE, Ng LL. Myeloperoxidase aids prognostication together with N-terminal pro-B-type natriuretic peptide in high-risk patients with acute ST elevation myocardial infarction. Heart. 2007;93:826–31.

    Article  CAS  PubMed  Google Scholar 

  18. Ndrepepa G, Braun S, Mehilli J, von Beckerath N, Schömig A, Kastrati A. Myeloperoxidase level in patients with stable coronary artery disease and acute coronary syndromes. Eur J Clin Invest. 2008;38:90–6.

    Article  CAS  PubMed  Google Scholar 

  19. Borges FK, Borges FK, Stella FS, et al. Serial analysis of C-reactive protein and myeloperoxidase in acute coronary syndrome. Clin Cardiol 2009;32:E58–62.

    Article  PubMed  Google Scholar 

  20. Zhang R, Brennan ML, Fu X, et al. Association between myeloperoxidase levels and risk of coronary artery disease. JAMA. 2001;286:2136–42.

    Article  CAS  PubMed  Google Scholar 

  21. Sugiyama S, Okada Y, Sukhova GK, Virmani R, Heinecke JW, Libby P. Macrophage myeloperoxidase regulation by granulocyte macrophage colony-stimulating factor in human atherosclerosis and implications in acute coronary syndromes. Am J Pathol. 2001;158:879–91.

    CAS  PubMed  Google Scholar 

  22. Tavora FR, Ripple M, Li L, Burke AP. Monocytes and neutrophils expressing myeloperoxidase occur in fibrous caps and thrombi in unstable coronary plaques. BMC Cardiovasc Disord. 2009;9:27.

    Article  PubMed  Google Scholar 

  23. Wainstein RV, Wainstein MV, Ribeiro JP, et al. Association between myeloperoxidase polymorphisms and its plasma levels with severity of coronary artery disease. Clin Biochem 2010;43:57–62.

    Article  CAS  PubMed  Google Scholar 

  24. Antman EM, Cohen M, Bernink PJLM, et al. The TIMI risk score for unstable angina/non-ST elevation MI: a method for prognostication and therapeutic decision making. JAMA. 2000;284:835–42.

    Article  CAS  PubMed  Google Scholar 

  25. Gensini GG. A more meaningful scoring system for determining the severity of coronary heart disease. Am J Cardiol. 1983;51:606.

    Article  CAS  PubMed  Google Scholar 

  26. Düzgünçinar O, Yavuz B, Hazirolan T, et al. Plasma myeloperoxidase is related to the severity of coronary artery disease. Acta Cardiol. 2008;63:147–52.

    Article  PubMed  Google Scholar 

  27. Cavusoglu E, Chopra V, Gupta A, et al. Usefulness of the white blood cell count as a predictor of angiographic findings in an unselected population referred for coronary angiography. Am J Cardiol. 2006;98:1189–93.

    Article  PubMed  Google Scholar 

  28. Kubala L, Lu G, Baldus S, Berglund L, Eiserich JP. Plasma levels of myeloperoxidase are not elevated in patients with stable coronary artery disease. Clin Chim Acta. 2008;394:59–62.

    Article  CAS  PubMed  Google Scholar 

  29. Rudolph TK, Rudolph V, Baldus S. Contribution of myeloperoxidase to smoking-dependent vascular inflammation. Proc Am Thorac Soc. 2008;5:820–3.

    Article  PubMed  Google Scholar 

  30. Goldmann BU, Rudolph V, Rudolph TK, et al. Neutrophil activation precedes myocardial injury in patients with acute myocardial infarction. Free Radic Biol Med. 2009;47:79–83.

    Article  CAS  PubMed  Google Scholar 

  31. Fragmin and Fast Revascularization during InStability in Coronary artery disease Investigators. Invasive compared with non-invasive treatment in unstable coronary artery disease: FRISC II prospective randomised multicentre study. Lancet 1999;354:708–15.

    Google Scholar 

  32. Cannon CP, Weintraub WS, Demopoulas LA, et al. Comparison of early invasive and conservative strategies in patients with acute coronary syndromes treated with the glycoprotein IIb/IIIa inhibitor tirofiban. N Eng J Med. 2001;344:1879–87.

    Article  CAS  Google Scholar 

  33. Wainstein MV, Bento da Silva D, Ribeiro JP. Coronary stent implantation may seal the inflammatory response in patients with acute coronary syndromes. Int J Cardiol. 2008;130:503–4.

    Article  PubMed  Google Scholar 

  34. Wainstein MV, Ribeiro JP. Mechanical plaque sealing in patients with acute coronary syndromes. Int J Cardiol. 2009;135:105–6.

    Article  Google Scholar 

  35. Wainstein MV, Ribeiro JP. What seals inflammation in patients with acute coronary syndromes. Int J Cardiol. 2009;135:108.

    Article  Google Scholar 

  36. Clausell N, Prado KF, Ribeiro JP. Increased plasma levels of soluble vascular cellular adhesion molecule 1 in patients with chest pain and angiographically normal coronary arteries. Int J Cardiol. 1999;68:275–80.

    Article  CAS  PubMed  Google Scholar 

  37. Metha SR, Granger CB, Boden WE, et al. Early versus delayed invasive intervention in acute coronary syndromes. N Eng J Med. 2009;360:2165–75.

    Article  Google Scholar 

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Authors and Affiliations

  1. Post-graduate Program in Cardiology, Faculty of Medicine, Federal University of Rio Grande do Sul, Rua Ramiro Barcelos 2350, CEP 90035-003, Porto Alegre, RS, Brazil

    Eraldo de Azevedo Lucio, Sandro C. Gonçalves, Jorge P. Ribeiro, Gilberto L. Nunes & Marco V. Wainstein

  2. Cardiology Division, Hospital de Clinicas de Porto Alegre, Porto Alegre, Brazil

    Jorge P. Ribeiro, Gustavo N. Araujo & Marco V. Wainstein

  3. Hospital São Francisco da Santa Casa de Porto Alegre, Porto Alegre, Brazil

    Eraldo de Azevedo Lucio & Gilberto L. Nunes

  4. Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, Brazil

    Jarbas R. de Oliveira

Authors
  1. Eraldo de Azevedo Lucio
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  2. Sandro C. Gonçalves
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  3. Jorge P. Ribeiro
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  4. Gilberto L. Nunes
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  5. Jarbas R. de Oliveira
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  6. Gustavo N. Araujo
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  7. Marco V. Wainstein
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Correspondence to Eraldo de Azevedo Lucio.

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Responsible Editor: Claudia Kasserra.

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de Azevedo Lucio, E., Gonçalves, S.C., Ribeiro, J.P. et al. Lack of association between plasma myeloperoxidase levels and angiographic severity of coronary artery disease in patients with acute coronary syndrome. Inflamm. Res. 60, 137–142 (2011). https://doi.org/10.1007/s00011-010-0247-8

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  • DOI: https://doi.org/10.1007/s00011-010-0247-8

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