Advertisement

Inflammation Research

, Volume 58, Issue 4, pp 192–197 | Cite as

Concentrations of α- and β-defensins in plasma of patients with inflammatory bowel disease

  • N. Yamaguchi
  • H. Isomoto
  • H. Mukae
  • H. Ishimoto
  • K. Ohnita
  • S. Shikuwa
  • Y. Mizuta
  • M. Nakazato
  • S. Kohno
Article

Abstract:

Background:

Impaired production/release of defensins, representative endogenous antimicrobial peptides, is associated with the pathogenesis of inflammatory bowel disease (IBD).

Material and methods:

Employing in house radioimmunoassay, we examined concentrations of the major forms α-defensins, human neutrophil peptides (HNP) 1–3 and human β-defensin (HBD)-2 in plasma of 55 IBD patients consisting of 29 patients with ulcerative colitis (UC) and 26 with Crohn’s disease (CD) and 57 controls.

Results:

The circulating HNP 1–3, but not HBD-2, levels in IBD patients were significantly higher than those in controls. Plasma HNP 1–3 concentrations in CD patients significantly correlated with Crohn’s disease activity index, peripheral white blood cell counts, serum CRP values and TNF-α levels.

Conclusions:

Elevation of circulating α-defensins levels is suggestive of their physiopathological roles in IBD. Plasma HNP 1–3 concentrations may be an indicator for CD activity and their association with CRP and TNF-α supports a possible association with the inflammatory process.

Keywords:

human neutrophil peptides 1–3 human β-defensin-2 inflammatory bowel disease ulcerative colitis Crohn’s disease 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Copyright information

© Birkhäuser Verlag, Basel 2009

Authors and Affiliations

  • N. Yamaguchi
    • 1
  • H. Isomoto
    • 1
  • H. Mukae
    • 1
  • H. Ishimoto
    • 1
  • K. Ohnita
    • 1
  • S. Shikuwa
    • 1
  • Y. Mizuta
    • 1
  • M. Nakazato
    • 2
  • S. Kohno
    • 1
  1. 1.Second Department of Internal MedicineNagasaki University School of MedicineNagasakiJapan
  2. 2.Third Department of Internal MedicineMiyazaki University School of MedicineMiyazakiJapan

Personalised recommendations